末端氧化酶与两亲分子的相互作用。

Interaction of Terminal Oxidases with Amphipathic Molecules.

机构信息

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskie Gory 1, Bld. 40, 119992 Moscow, Russia.

出版信息

Int J Mol Sci. 2023 Mar 29;24(7):6428. doi: 10.3390/ijms24076428.

DOI:10.3390/ijms24076428

PMID:37047401

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10095113/

Abstract

The review focuses on recent advances regarding the effects of natural and artificial amphipathic compounds on terminal oxidases. Terminal oxidases are fascinating biomolecular devices which couple the oxidation of respiratory substrates with generation of a proton motive force used by the cell for ATP production and other needs. The role of endogenous lipids in the enzyme structure and function is highlighted. The main regularities of the interaction between the most popular detergents and terminal oxidases of various types are described. A hypothesis about the physiological regulation of mitochondrial-type enzymes by lipid-soluble ligands is considered.

摘要

本综述重点介绍了天然和人工两亲性化合物对末端氧化酶影响的最新进展。末端氧化酶是一种迷人的生物分子装置，它将呼吸底物的氧化与质子动力的产生耦合起来，细胞利用质子动力产生 ATP 和满足其他需求。本文强调了内源性脂质在酶结构和功能中的作用。描述了最受欢迎的清洁剂与各种类型的末端氧化酶之间相互作用的主要规律。还考虑了关于脂溶性配体对线粒体酶进行生理调节的假说。