比利时性工作者中生殖器支原体的大环内酯类耐药性。
Macrolide resistance in Mycoplasma genitalium from female sex workers in Belgium.
机构信息
Department of Laboratory Medicine, Ghent University Hospital, Corneel Heymanslaan 10, 9000 Ghent, Belgium; Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Corneel Heymanslaan 10, 9000 Ghent, Belgium.
PASOP VZW, Brabantdam 100, 9000 Ghent, Belgium.
出版信息
J Glob Antimicrob Resist. 2018 Mar;12:149-152. doi: 10.1016/j.jgar.2017.09.018. Epub 2017 Oct 5.
OBJECTIVES
Mycoplasma genitalium is emerging as an aetiological agent of sexually transmitted infections (STIs). Although M. genitalium is commonly treated with azithromycin, macrolide resistance associated with point mutations in the 23S rRNA gene is emerging.
METHODS
In this study, the prevalence of M. genitalium and macrolide resistance in female sex workers (FSW) in Belgium was evaluated by a prospective study conducted between 2015 and 2016. Vaginal swabs were sampled from 303 FSW who underwent testing for M. genitalium along with standard STI screening. All samples positive for M. genitalium were subsequently tested for mutations associated with macrolide resistance.
RESULTS
M. genitalium was detected in 10.8% of participants and macrolide resistance-associated mutations (A2058G and A2059G) were found in 6.5% of isolates.
CONCLUSIONS
M. genitalium is clearly present in FSW in Belgium. In contrast to other reports, for now the occurrence of macrolide resistance appears limited in this specific target population.
目的
生殖支原体正在成为性传播感染（STI）的一种病因。尽管生殖支原体通常用阿奇霉素治疗，但与 23S rRNA 基因点突变相关的大环内酯类耐药性正在出现。
方法
本研究通过 2015 年至 2016 年期间进行的一项前瞻性研究，评估了比利时性工作者（FSW）中生殖支原体和大环内酯类耐药的流行情况。从 303 名接受生殖支原体检测和标准 STI 筛查的 FSW 中采集阴道拭子样本。所有检测出生殖支原体阳性的样本均随后检测与大环内酯类耐药相关的突变。
结果
在 10.8%的参与者中检测到生殖支原体，在 6.5%的分离株中发现大环内酯类耐药相关突变（A2058G 和 A2059G）。
结论
在比利时的 FSW 中，生殖支原体显然存在。与其他报告相比，目前大环内酯类耐药的发生在这个特定的目标人群中似乎有限。
Zotero 插件