Zhao Xin, Lü Ben, Wang Erhua
Department of Hematology, Third Xiangya Hospital, Central South University, Changsha 410013; Laboratory of Medical Genetics, Central South University, Changsha 410078, China.
Department of Hematology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2017 Sep 28;42(9):1111-1115. doi: 10.11817/j.issn.1672-7347.2017.09.019.
High mobility group box-1 (HMGB1) is an evolutionarily conserved protein, which widely exists in mammals. HMGB1 contains the nucleus localization sequences. Intracellular and extracellular HMGB1 shows different biological functions. Extracellular HMGB1 is closely related to sepsis, cancer, rheumatoid immune, atherosclerosis, ischemia-reperfusion injury and so on. The mobilization of HMGB1 from the nucleus to the cytoplasm and subsequent release involves the processes of post-translation modification, active secretion and nuclear localization.
高迁移率族蛋白B1（HMGB1）是一种进化上保守的蛋白质，广泛存在于哺乳动物中。HMGB1含有核定位序列。细胞内和细胞外的HMGB1具有不同的生物学功能。细胞外HMGB1与脓毒症、癌症、类风湿性免疫、动脉粥样硬化、缺血再灌注损伤等密切相关。HMGB1从细胞核向细胞质的转运以及随后的释放涉及翻译后修饰、主动分泌和核定位过程。
