Blumenkopf B
Department of Neurological Surgery, Vanderbilt University School of Medicine, Nashville, Tenn.
Appl Neurophysiol. 1988;51(2-5):89-103. doi: 10.1159/000099952.
The dorsal horn region of the spinal cord, particularly the dorsal root entry zone (DREZ), represents the first central integration center for nociceptive afferent impulses. Here, the excitatory neurotransmitters/modulators, products of the primary sensory neurons, are released, the segmental interneuronal influences pertain, and the descending bulbospinal tracts terminate. A vast variety of compounds are thus involved in the processing of nociceptive information in these areas, among which are the 'classical' neurotransmitters and the more recently described neuropeptides. A continued vast interest exists concerning the chemistry of the dorsal horn/DREZ region. The current developments and understanding regarding the pharmacology of this region are presented. Particular emphasis is given to the interactions among the various compounds, the coexistence of some of these within single neuronal populations, the importance of the opiate receptor subtypes, and the actions and localizations of some of the newly discovered neuropeptides.
脊髓背角区域，尤其是背根入髓区（DREZ），是伤害性传入冲动的首个中枢整合中心。在这里，初级感觉神经元的兴奋性神经递质/调质被释放，节段性中间神经元产生影响，下行的延髓脊髓束终止。因此，多种化合物参与了这些区域伤害性信息的处理，其中包括“经典”神经递质和最近描述的神经肽。人们对背角/DREZ区域的化学性质一直有着浓厚的兴趣。本文介绍了该区域药理学的当前进展和认识。特别强调了各种化合物之间的相互作用、其中一些在单个神经元群体中的共存、阿片受体亚型的重要性以及一些新发现神经肽的作用和定位。
