Verma Kirti Dhingra, Massing Justin O, Kamper Sarah G, Carney Christiane E, MacRenaris Keith W, Basilion James P, Meade Thomas J
Department of Biomedical Engineering , Case Center for Imaging Research , The NFCR Center for Molecular Imaging , Case Western Reserve University , Cleveland , Ohio 44106-7207 , USA.
Department of Chemistry , Molecular Biosciences, Neurobiology , Biomedical Engineering, and Radiology , Northwestern University , 2145 Sheridan Road , Evanston , Illinois 60208-3113 , USA.
Chem Sci. 2017 Aug 1;8(8):5764-5768. doi: 10.1039/c7sc02217d. Epub 2017 Jun 13.
Visualizing disease heterogeneity remains a challenging task since most imaging agents are targeted to a single receptor. We describe the development of an MR platform able to report on multiple molecular events. Enzyme activation and enhanced cellular uptake of this modular probe make it suitable for subsequent targeted-reporter imaging applications.
由于大多数成像剂都靶向单一受体，可视化疾病异质性仍然是一项具有挑战性的任务。我们描述了一种能够报告多种分子事件的磁共振平台的开发。这种模块化探针的酶激活和增强的细胞摄取使其适用于后续的靶向报告成像应用。
