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80岁及以上患者脊柱手术相关并发症:日本雄心勃勃的脊柱外科医生协会(JASA)多中心研究

Complications Associated With Spine Surgery in Patients Aged 80 Years or Older: Japan Association of Spine Surgeons with Ambition (JASA) Multicenter Study.

作者信息

Kobayashi Kazuyoshi, Imagama Shiro, Ando Kei, Ishiguro Naoki, Yamashita Masaomi, Eguchi Yawara, Matsumoto Morio, Ishii Ken, Hikata Tomohiro, Seki Shoji, Terai Hidetomi, Suzuki Akinobu, Tamai Koji, Aramomi Masaaki, Ishikawa Tetsuhiro, Kimura Atsushi, Inoue Hirokazu, Inoue Gen, Miyagi Masayuki, Saito Wataru, Yamada Kei, Hongo Michio, Nishimura Hirosuke, Suzuki Hidekazu, Nakano Atsushi, Watanabe Kazuyuki, Chikuda Hirotaka, Ohya Junichi, Aoki Yasuchika, Shimizu Masayuki, Futatsugi Toshimasa, Mukaiyama Keijiro, Hasegawa Masaichi, Kiyasu Katsuhito, Iizuka Haku, Iizuka Yoichi, Kobayashi Ryoichi, Nishida Kotaro, Kakutani Kenichiro, Nakajima Hideaki, Murakami Hideki, Demura Satoru, Kato Satoshi, Yoshioka Katsuhito, Namikawa Takashi, Watanabe Kei, Nakanishi Kazuyoshi, Nakagawa Yukihiro, Yoshimoto Mitsunori, Fujiwara Hiroyasu, Nishida Norihiro, Imajo Yasuaki, Yamazaki Masashi, Sakane Masataka, Abe Tetsuya, Fujii Kengo, Kaito Takashi, Furuya Takeo, Orita Sumihisa, Ohtori Seiji

机构信息

Nagoya University, Nagoya, Japan.

Japan Community Health Care Organization Funabashi Central Hospital, Chiba, Japan.

出版信息

Global Spine J. 2017 Oct;7(7):636-641. doi: 10.1177/2192568217716144. Epub 2017 Jul 20.

Abstract

STUDY DESIGN

Retrospective study of registry data.

OBJECTIVES

Aging of society and recent advances in surgical techniques and general anesthesia have increased the demand for spinal surgery in elderly patients. Many complications have been described in elderly patients, but a multicenter study of perioperative complications in spinal surgery in patients aged 80 years or older has not been reported. Therefore, the goal of the study was to analyze complications associated with spine surgery in patients aged 80 years or older with cervical, thoracic, or lumbar lesions.

METHODS

A multicenter study was performed in patients aged 80 years or older who underwent 262 spinal surgeries at 35 facilities. The frequency and severity of complications were examined for perioperative complications, including intraoperative and postoperative complications, and for major postoperative complications that were potentially life threatening, required reoperation in the perioperative period, or left a permanent injury.

RESULTS

Perioperative complications occurred in 75 of the 262 surgeries (29%) and 33 were major complications (13%). In multivariate logistic regression, age over 85 years (hazard ratio [HR] = 1.007, = 0.025) and estimated blood loss ≥500 g (HR = 3.076, = .004) were significantly associated with perioperative complications, and an operative time ≥180 min (HR = 2.78, = .007) was significantly associated with major complications.

CONCLUSIONS

Elderly patients aged 80 years or older with comorbidities are at higher risk for complications. Increased surgical invasion, and particularly a long operative time, can cause serious complications that may be life threatening. Therefore, careful decisions are required with regard to the surgical indication and procedure in elderly patients.

摘要

研究设计

对登记数据的回顾性研究。

目的

社会老龄化以及外科技术和全身麻醉的最新进展增加了老年患者脊柱手术的需求。老年患者中已描述了许多并发症,但尚未有关于80岁及以上患者脊柱手术围手术期并发症的多中心研究报告。因此,本研究的目的是分析80岁及以上患有颈椎、胸椎或腰椎病变的患者脊柱手术相关的并发症。

方法

对在35家机构接受262例脊柱手术的80岁及以上患者进行了一项多中心研究。检查围手术期并发症(包括术中及术后并发症)以及可能危及生命、需要在围手术期再次手术或造成永久性损伤的主要术后并发症的发生频率和严重程度。

结果

262例手术中有75例发生围手术期并发症(29%),33例为主要并发症(13%)。在多因素逻辑回归分析中,85岁以上(风险比[HR]=1.007,P=0.025)和估计失血量≥500克(HR=3.076,P=0.004)与围手术期并发症显著相关,手术时间≥180分钟(HR=2.78,P=0.007)与主要并发症显著相关。

结论

患有合并症的80岁及以上老年患者并发症风险更高。手术侵袭性增加,尤其是手术时间长,可导致可能危及生命的严重并发症。因此,对于老年患者的手术适应症和手术方式需要谨慎决策。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6038/5624380/e9d499ecbe89/10.1177_2192568217716144-fig1.jpg

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