Department of Neurological Surgery, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
J Neurosurg Spine. 2011 Dec;15(6):667-74. doi: 10.3171/2011.7.SPINE10640. Epub 2011 Sep 2.
As the population continues to age, relatively older geriatric patients will present more frequently with complex spinal deformities that may require surgical intervention. To the authors' knowledge, no study has analyzed factors predictive of complications after major spinal deformity surgery in the very elderly (75 years and older). The authors' objective was to determine the rate of minor and major complications and predictive factors in patients 75 years of age and older who underwent major spinal deformity surgery requiring a minimum 5-level arthrodesis procedure.
Twenty-one patients who were 75 years of age or older and underwent thoracic and/or lumbar fixation and arthrodesis across 5 or more levels for spinal deformity were analyzed retrospectively. The medical and surgical records were reviewed in detail. Age, diagnosis, comorbidities, operative data, hospital data, major and minor complications, and deaths were recorded. Factors predictive of perioperative complications were identified by logistic regression analysis.
The mean patient age was 77 years old (range 75-83 years). There were 14 women and 7 men. The mean follow-up was 41.2 months (range 24-81 months). Fifteen patients (71%) had at least 1 comorbidity. A mean of 10.5 levels were fused (range 5-15 levels). Thirteen patients (62%) had at least 1 perioperative complication, and 8 (38%) had at least one major complication for a total of 17 complications. There were no perioperative deaths. Increasing age was predictive of any perioperative complication (p = 0.03). However, major complications were not predicted by age or comorbidities as a whole. In a subset analysis of comorbidities, only hypertension was predictive of a major complication (OR 10, 95% CI 1.3-78; p = 0.02). Long-term postoperative complications occurred in 11 patients (52%), and revision fusion surgery was necessary in 3 (14%).
Patients 75 years and older undergoing major spinal deformity surgery have an overall perioperative complication rate of 62%, with older age increasing the likelihood of a complication, and a long-term postoperative complication rate of 52%. Patients in this age group with a history of hypertension are 10 times more likely to incur a major perioperative complication. However, the mortality risk for these patients is not increased.
随着人口老龄化,相对较年长的老年患者将更频繁地出现复杂的脊柱畸形,可能需要手术干预。据作者所知,尚无研究分析过 75 岁及以上的老年患者行大型脊柱畸形手术后发生并发症的预测因素。作者的目的是确定在接受至少 5 个节段融合的胸椎和/或腰椎固定和融合以矫正脊柱畸形的 75 岁及以上患者中,小并发症和大并发症的发生率以及预测因素。
回顾性分析了 21 例年龄在 75 岁及以上、行胸椎和/或腰椎固定和融合、融合 5 个或以上节段以矫正脊柱畸形的患者。详细回顾了他们的医疗和手术记录。记录了年龄、诊断、合并症、手术数据、住院数据、大并发症和小并发症以及死亡情况。通过逻辑回归分析确定了围手术期并发症的预测因素。
患者的平均年龄为 77 岁(75-83 岁)。其中 14 例为女性,7 例为男性。平均随访时间为 41.2 个月(24-81 个月)。15 例(71%)至少有 1 种合并症。平均融合 10.5 个节段(5-15 个节段)。13 例(62%)至少有 1 种围手术期并发症,8 例(38%)至少有 1 种大并发症,总共有 17 种并发症。围手术期内无死亡病例。年龄增长与任何围手术期并发症相关(p = 0.03)。然而,年龄或整体合并症并不能预测大并发症。在合并症的亚组分析中,只有高血压是大并发症的预测因素(OR 10,95%CI 1.3-78;p = 0.02)。11 例(52%)患者出现长期术后并发症,3 例(14%)需要再次行融合手术。
75 岁及以上行大型脊柱畸形手术的患者总体围手术期并发症发生率为 62%,年龄增长会增加发生并发症的可能性,长期术后并发症发生率为 52%。有高血压病史的该年龄组患者发生大围手术期并发症的风险增加 10 倍。然而,这些患者的死亡风险并未增加。