溴氰菊酯诱导了来自美洲大赤鱿视叶的突触体中胆碱转运和磷酸化活性的变化。

Deltamethrin induced changes in choline transport and phosphorylation activities in synaptosomes from the optic lobe of squid, Loligo pealei.

Matsumura F

Pesticide Research Center, Michigan State University, East Lansing 48824.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1988;89(2):179-83. doi: 10.1016/0742-8413(88)90206-x.

Abstract

Deltamethrin, a powerful synthetic pyrethroid causes a significant change in choline transport in freshly prepared synaptosomes from squid optic lobes. 2. At resting state (nondepolarized) such an effect manifested as a reduction of 14C-choline uptake in a short term (1 min) uptake experiment. 3. At depolarized state, or under conditions where synaptosomes are subjected to osmotic, aging and other stress conditions, deltamethrin caused stimulation of 14C-choline uptake, resulting in elevation of the levels of total radiocarbons in synaptosomes. 4. Such changes are accompanied with changes in overall phosphorylation activities in synaptosomes.

摘要

溴氰菊酯是一种强效合成拟除虫菊酯，它会使鱿鱼视叶新鲜制备的突触体中的胆碱转运发生显著变化。2. 在静息状态（非去极化）下，这种效应在短期（1分钟）摄取实验中表现为14C - 胆碱摄取减少。3. 在去极化状态下，或在突触体受到渗透、老化和其他应激条件的情况下，溴氰菊酯会刺激14C - 胆碱摄取，导致突触体中总放射性碳水平升高。4. 这些变化伴随着突触体中整体磷酸化活性的变化。