盐溶液中离子成分对氯菊酯和甲氧滴滴涕诱导的去极化后电位的影响。

Effect of ionic contents in saline on depolarizing afterpotential induced by phenothrin and methoxychlor.

Nishimura K, Fujita T

Department of Agricultural Chemistry, Kyoto University, Japan.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1988;89(2):389-94. doi: 10.1016/0742-8413(88)90243-5.

Abstract

The depolarizing afterpotential induced by phenothrin and methoxychlor in crayfish giant axons was measured intracellularly. 2. Changes in the K+ ion concentration did not affect the depolarizing afterpotential when evaluated as the membrane potential. 3. Addition of tetrodotoxin or replacement of the Cl- ions by OAc- ions or of the Na+ ions by choline ions reduced the depolarizing afterpotential and the action potential. 4. A ratio of the reduction of the depolarizing afterpotential in saline that contained OAc- ions to that of the action potential was similar to that measured in the saline containing tetrodotoxin. 5. With the increase in the choline concentration, the relative value of the depolarizing afterpotential to that measured before the replacement decreased almost linearly with that of the decrease in the action potential.

摘要

在小龙虾巨轴突中，采用细胞内记录法测量了苯醚菊酯和甲氧滴滴涕诱导的去极化后电位。2. 当以膜电位进行评估时，钾离子浓度的变化并未影响去极化后电位。3. 添加河豚毒素，或将氯离子替换为醋酸根离子，或将钠离子替换为胆碱离子，均会降低去极化后电位和动作电位。4. 在含有醋酸根离子的盐溶液中，去极化后电位的降低比例与动作电位的降低比例之比，与在含有河豚毒素的盐溶液中测得的比例相似。5. 随着胆碱浓度的增加，去极化后电位相对于替换前测量值的相对值，几乎与动作电位的降低呈线性下降。