无创性评估左心室充盈压。
Non-invasive assessment of left ventricular filling pressure.
机构信息
Methodist DeBakey Heart and Vascular Center, and Cardiovascular Imaging Institute, The Methodist Hospital, Houston, TX, USA.
出版信息
Eur J Heart Fail. 2018 Jan;20(1):38-48. doi: 10.1002/ejhf.971. Epub 2017 Oct 8.
Dyspnoea is a presenting symptom for patients with heart failure. It is often due to elevated left ventricular (LV) filling pressure but can be due to pulmonary disease or other non-cardiac reasons. While physical examination is useful, it has its limitations. Accordingly, non-invasive imaging has an important role in the diagnostic evaluation of patients with known or suspected heart failure. Echocardiography is usually the first test obtained and is used to determine LV volumes, ejection fraction and mass as well as right ventricular size and function, left and right atrial volumes, valvular lesions, and pulmonary artery pressures. Additionally, LV filling pressure can be estimated. A recent algorithm was published that depends on clinical, two-dimensional data and Doppler signals. The algorithm is accurate in patients with depressed and normal ejection fraction. There are other measurements that can be obtained as LV strain and diastolic strain rate and left atrial strain. These indices provide valuable insight into LV relaxation and filling pressure as well as left atrial function. Assessment of LV filling pressure has been evaluated most extensively in patients in sinus rhythm. However, it is also possible to assess LV filling and draw inferences about LV filling pressure in patients in atrial fibrillation, in patients with mitral valve disease and in patients with left ventricular assist devices. Left ventricular filling has been assessed by other imaging modalities, including cardiac computed tomography and cardiac magnetic resonance. While these other imaging modalities may be needed in some cases, echocardiography has the highest feasibility and validation, and the most practical application.
呼吸困难是心力衰竭患者的主要症状。呼吸困难通常是由于左心室充盈压升高引起的,但也可能是由于肺部疾病或其他非心脏原因引起的。虽然体格检查很有用,但它也有其局限性。因此,非侵入性成像在心力衰竭患者的诊断评估中具有重要作用。超声心动图通常是获得的第一个测试,用于确定左心室容积、射血分数和质量,以及右心室大小和功能、左、右心房容积、瓣膜病变和肺动脉压力。此外,还可以估计左心室充盈压。最近发表了一个依赖于临床、二维数据和多普勒信号的算法。该算法在射血分数降低和正常的患者中准确。还可以获得其他测量值,如左心室应变和舒张应变率以及左心房应变。这些指标提供了对左心室舒张和充盈压力以及左心房功能的有价值的了解。LV 充盈压力的评估在窦性心律患者中得到了最广泛的评估。然而,在心房颤动患者、二尖瓣疾病患者和左心室辅助装置患者中,也可以评估 LV 充盈并推断 LV 充盈压力。其他成像方式,包括心脏计算机断层扫描和心脏磁共振,也可以评估左心室充盈。虽然在某些情况下可能需要其他成像方式,但超声心动图具有最高的可行性和验证性,以及最实际的应用。