手性铑催化脂肪族亚胺的烯丙基化反应。
Enantioselective Rhodium-Catalyzed Alkenylation of Aliphatic Imines.
机构信息
Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , Shanghai 200032, P.R. China.
Jiangsu Key Laboratory of Chiral Drug Development, Jiangsu Aosaikang Pharmaceutical Co., Ltd. , Nanjing, Jiangsu 211112, P.R. China.
出版信息
Org Lett. 2017 Oct 20;19(20):5601-5604. doi: 10.1021/acs.orglett.7b02737. Epub 2017 Oct 9.
An efficient, enantioselective rhodium-catalyzed addition of potassium alkenyltrifluoroborates to N-nosyl aliphatic imines has been realized. Good reaction yields and excellent enantioselectivities (94-99% ee) were obtained for a variety of aliphatic imines and nucleophilic alkenyltrifluoroborates. An active rhodium-diene catalyst and the precise reaction condition control proved to be pivotal for success.
一种高效、对映选择性的铑催化钾烯基三氟硼酸盐与 N-硝基亚烷基亚胺的加成反应已经实现。对于各种脂肪族亚胺和亲核烯基三氟硼酸盐，该反应获得了良好的反应收率和优异的对映选择性（94-99%ee）。活性铑-二烯催化剂和精确的反应条件控制被证明是成功的关键。
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