The George Washington University Medical Center, Washington, District of Columbia (Drs Haines, Dickens, Levine); Department of Veterans Affairs Medical Center, East Orange, New Jersey (Dr Ottenweller); and Department of Medical Laboratory Sciences, Kuwait University Faculty of Health Sciences, Sulaibikhat, Kuwait (Dr Mahmoud).
J Occup Environ Med. 2017 Oct;59(10):1000-1006. doi: 10.1097/JOM.0000000000001129.
Two groups of Gulf War era veterans, one exhibiting blurred vision, balance problems/dizziness, tremors/shaking, and speech difficulty and a second group with post-traumatic stress disorder (PTSD), but not the neurologic syndrome, were assessed for organophosphate-detoxifying enzyme paraoxonase/arylesterase (PON1) and its Q/R isoforms, butyrylcholinesterase (BuChE) and its U/A isoforms and cytokines.
Defibrinated peripheral blood was evaluated for enzymes and cytokines.
Trends toward elevation of Th2 cytokines interleukin-4 (IL-4) and IL-13 were observed in subjects with neurologic syndrome. Neither the activities nor isoforms of the enzyme, the neurologic symptoms, nor PTSD had any relationship to wartime deployment to the theater of combat.
The negative outcomes described above suggest that exposure to organophosphates or other agents normally detoxified by PON1 and BuChE may not have contributed significantly to neurologic components of Gulf War Illness.
两组海湾战争时期的退伍军人，一组表现出视力模糊、平衡问题/头晕、震颤/颤抖和言语困难，另一组患有创伤后应激障碍（PTSD）但没有神经系统综合征，评估有机磷解毒酶对氧磷酶/芳基酯酶（PON1）及其 Q/R 同工型、丁酰胆碱酯酶（BuChE）及其 U/A 同工型和细胞因子。
用脱纤维外周血评估酶和细胞因子。
在有神经系统综合征的受试者中，观察到 Th2 细胞因子白细胞介素-4（IL-4）和白细胞介素-13升高的趋势。酶的活性和同工型、神经系统症状或 PTSD 均与战时部署到战区无关。
上述负面结果表明，接触有机磷或其他通常由 PON1 和 BuChE 解毒的药物可能不会对海湾战争疾病的神经系统成分产生重大影响。
