Jackson D M, Ross S B, Hashizume M
Department of Pharmacology, University of Sydney, New South Wales, Australia.
J Pharm Pharmacol. 1988 Mar;40(3):221-3. doi: 10.1111/j.2042-7158.1988.tb05228.x.
The ability of bromocriptine and SKF38393 (2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine) to produce some dopamine-mediated behaviours has been assessed in mice. Soon after injection, SKF38393 produced moderate increases in grooming and sniffing which were not very intense, while bromocriptine (with or without SKF38393) inhibited all grooming behaviour. Bromocriptine alone also depressed rearing and sniffing in the first hour and SKF38393 alone was without effect on rearing, but the combination produced a marked increase in the incidence of both rearing and sniffing, both of which behaviours appeared to be stereotyped. When bromocriptine-induced locomotor stimulation was peaking about 3 h after injection, as measured in automated activity cages in previous studies, there was an increase in sniffing and rearing, the incidence of which was unaffected by the addition of SKF38393, perhaps due to the shorter duration of action of SKF38393 than of bromocriptine. The data indicate that the D-1 agonist SKF38393 can qualitatively and quantitatively alter the behavioural spectrum produced by the D-2 agonist bromocriptine.
已在小鼠中评估了溴隐亭和SKF38393（2,3,4,5-四氢-7,8-二羟基-1-苯基-1H-3-苯并氮杂卓）产生某些多巴胺介导行为的能力。注射后不久，SKF38393使理毛和嗅探行为适度增加，但强度不是很大，而溴隐亭（无论有无SKF38393）均抑制所有理毛行为。单独使用溴隐亭在最初1小时内也会抑制竖毛和嗅探行为，单独使用SKF38393对竖毛行为无影响，但二者联合使用会使竖毛和嗅探行为的发生率显著增加，这两种行为似乎都具有刻板性。如先前研究在自动活动箱中所测，注射后约3小时溴隐亭诱导的运动刺激达到峰值时，嗅探和竖毛行为增加，添加SKF38393对其发生率无影响，这可能是由于SKF38393的作用持续时间比溴隐亭短。数据表明，D-1激动剂SKF38393可在质量和数量上改变D-2激动剂溴隐亭产生的行为谱。
