老年人肺部疾病：细胞机制。

Lung Diseases of the Elderly: Cellular Mechanisms.

机构信息

Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Miami Leonard M. Miller School of Medicine, 1600 Northwest 10th Avenue RMSB 7056 (D-60), Miami, FL 33136, USA.

DeWitt Daughtry Family Department of Surgery, University of Miami Leonard M. Miller School of Medicine, 1600 NW 10th Avenue, Miami, FL 33136, USA.

出版信息

Clin Geriatr Med. 2017 Nov;33(4):473-490. doi: 10.1016/j.cger.2017.07.001. Epub 2017 Aug 18.

DOI:10.1016/j.cger.2017.07.001

PMID:28991645

Abstract

Natural lung aging is characterized by molecular and cellular changes in multiple lung cell populations. These changes include shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, apoptosis, and stem cell exhaustion. Aging, combined with the loss of protective repair processes, correlates with the development and incidence of chronic respiratory diseases, including idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Ultimately, it is the interplay of age-related changes in biology and the subsequent responses to environmental exposures that largely define the physiology and clinical course of the aging lung.

摘要

自然肺老化的特征是多种肺细胞群体的分子和细胞变化。这些变化包括端粒缩短、细胞衰老标志物表达增加、DNA 损伤增加、氧化应激、细胞凋亡和干细胞耗竭。衰老，加上保护性修复过程的丧失，与慢性呼吸道疾病的发展和发生有关，包括特发性肺纤维化和慢性阻塞性肺疾病。最终，生物学相关的年龄变化与随后对环境暴露的反应之间的相互作用在很大程度上决定了老化肺的生理学和临床过程。