Entriken Catherine, Pritts Timothy A
Section of General Surgery, Department of Surgery, University of Cincinnati, Cincinnati, OH USA.
Curr Geriatr Rep. 2021;10(4):167-174. doi: 10.1007/s13670-021-00369-3. Epub 2021 Nov 9.
With the projected increase in the geriatric patient population, it is of the utmost importance to understand and optimize conditions in the perioperative period to ensure the best surgical outcome. Age-associated changes in respiratory physiology affect the surgical management of geriatric patients. This review focuses on perioperative pulmonary management of elderly individuals.
The physiological changes associated with aging include both physical and biochemical alterations that are detrimental to pulmonary function. There is an increased prevalence of chronic lung disease such as COPD and interstitial lung disease which can predispose patients to postoperative pulmonary complications. Additionally, elderly patients, especially those with chronic lung disease, are at risk for frailty. Screening tools have been developed to evaluate risk and aid in the judicious selection of patients for surgical procedures. The concept of "prehabilitation" has been developed to best prepare patients for surgery and may be more influential in the reduction of postoperative pulmonary complications than postoperative rehabilitation. Understanding the age-associated changes in metabolism of drugs has led to dose adjustments in the intraoperative and postoperative periods, reducing respiratory depression and lung protective ventilation and minimally invasive procedures have yielded reductions in postoperative pulmonary complications.
The perioperative management of the geriatric population can be divided into three key areas: preoperative risk mitigation, intraoperative considerations, and postoperative management. Preoperative considerations include patient selection and thorough history and physical, along with smoking cessation and prehabilitation in a subset of patients. Operative aspects include careful selection of anesthetic agents, lung protective ventilation, and choice of surgical procedure. Postoperative management should focus on selective use of agents that may contribute to respiratory depression and encouragement of rehabilitation.
随着老年患者数量预计增加,了解并优化围手术期情况以确保最佳手术结果至关重要。呼吸生理学中与年龄相关的变化会影响老年患者的手术管理。本综述聚焦于老年患者的围手术期肺部管理。
与衰老相关的生理变化包括对肺功能有害的物理和生化改变。慢性肺病如慢性阻塞性肺疾病(COPD)和间质性肺病的患病率增加,这会使患者易发生术后肺部并发症。此外,老年患者,尤其是患有慢性肺病的患者,存在虚弱风险。已开发出筛查工具来评估风险并有助于明智地选择手术患者。“术前康复”概念已被提出,以让患者为手术做好最佳准备,并且在减少术后肺部并发症方面可能比术后康复更具影响力。了解与年龄相关的药物代谢变化已导致在术中和术后调整剂量,减少呼吸抑制,肺保护性通气和微创手术已使术后肺部并发症减少。
老年患者的围手术期管理可分为三个关键领域:术前风险降低、术中注意事项和术后管理。术前考虑包括患者选择、全面的病史和体格检查,以及部分患者的戒烟和术前康复。手术方面包括谨慎选择麻醉剂、肺保护性通气和手术方式的选择。术后管理应侧重于选择性使用可能导致呼吸抑制的药物,并鼓励康复。