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免疫疗法是一种具有全新副作用特征的癌症治疗方法。

[Immunotherapy is cancer treatment with a novel side-effect profile].

作者信息

Kondrup Maria, Raunkilde Louise, Svane Inge Marie, Schmidt Henrik, Bastholt Lars

出版信息

Ugeskr Laeger. 2017 Oct 2;179(40).

Abstract

Within the last few years we have treated still more types of cancer with immune checkpoint inhibitors - anti-cytotoxic T-lymphocyte-associated-4 antibodies and anti-program-med cell death 1/anti-programmed cell death ligand 1 antibodies. A unique set of side effects called immune related adverse events irAEs may occur during treatment. Although severe irAEs remain rare they can become life-threatening. Early detection of irAEs and initiation of relevant treatment are therefore crucial to reduce the risk of long-term seque-lae. We provide a detailed overview of irAEs and recommendations for treatment according to established guidelines.

摘要

在过去几年里,我们使用免疫检查点抑制剂——抗细胞毒性T淋巴细胞相关蛋白4抗体和抗程序性细胞死亡蛋白1/抗程序性细胞死亡配体1抗体治疗了更多类型的癌症。在治疗过程中可能会出现一组独特的副作用,称为免疫相关不良事件(irAEs)。尽管严重的irAEs仍然很少见,但可能会危及生命。因此,早期发现irAEs并启动相关治疗对于降低长期后遗症的风险至关重要。我们根据既定指南提供了irAEs的详细概述和治疗建议。

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