地西泮治疗可减少实验性自身免疫性脑脊髓炎大鼠中枢神经系统中的炎症细胞和介质。
Diazepam treatment reduces inflammatory cells and mediators in the central nervous system of rats with experimental autoimmune encephalomyelitis.
作者信息
Fernández Hurst Nicolás, Zanetti Samanta R, Báez Natalia S, Bibolini Mario J, Bouzat Cecilia, Roth German A
机构信息
Departamento de Química Biológica "Ranwel Caputto", Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, X5000HUA Córdoba, Argentina; Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC, CONICET-UNC), Universidad Nacional de Córdoba, X5000HUA Córdoba, Argentina.
Instituto de Investigaciones Bioquímicas de Bahía Blanca (INIBIBB, CONICET-UNS), Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, 8000 Bahía Blanca, Argentina.
出版信息
J Neuroimmunol. 2017 Dec 15;313:145-151. doi: 10.1016/j.jneuroim.2017.09.012. Epub 2017 Sep 30.
Benzodiazepines are psychoactive drugs and some of them also affect immune cells. We here characterized the inflammatory and infiltrating immune cells in the central nervous system (CNS) during the acute phase of experimental autoimmune encephalomyelitis (EAE) in animals treated with Diazepam. Also, we evaluated the expression of Translocator Protein (18kDa) (TSPO), which is a biomarker of neuroinflammatory diseases. The results indicate that Diazepam exerts protective effects on EAE development, decreasing the incidence of the disease and reducing the number of inflammatory cells in CNS, with a concomitant decrease of TSPO levels in brain tissue and CNS inflammatory CD11b cells.
苯二氮䓬类药物是精神活性药物，其中一些还会影响免疫细胞。我们在此对用安定治疗的动物实验性自身免疫性脑脊髓炎（EAE）急性期中枢神经系统（CNS）中的炎性和浸润性免疫细胞进行了表征。此外，我们评估了转运体蛋白（18 kDa）（TSPO）的表达，它是神经炎症性疾病的生物标志物。结果表明，安定对EAE的发展具有保护作用，可降低疾病的发病率并减少CNS中的炎性细胞数量，同时脑组织和CNS炎性CD11b细胞中的TSPO水平也随之降低。
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