Unidad de Metabolismo Óseo, Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Universitario Campus de la Salud, Instituto de Investigación Biosanitaria de Granada, Granada, España; Departamento de Medicina, Universidad de Granada, Granada, España.
Unidad de Metabolismo Óseo, Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Universitario Campus de la Salud, Instituto de Investigación Biosanitaria de Granada, Granada, España; Departamento de Medicina, Universidad de Granada, Granada, España.
Med Clin (Barc). 2018 Mar 23;150(6):226-232. doi: 10.1016/j.medcli.2017.07.020. Epub 2017 Oct 6.
Primary hyperparathyroidism (PHPT) is a common endocrinological process, characterized by chronic elevation of serum concentrations of calcium and parathyroid hormone (PTH). Many years ago, the most frequent forms of clinical presentation were symptomatic renal or skeletal disease with moderate or severe hypercalcemia; however, currently, most patients have few symptoms and mild hypercalcemia. A new form of presentation called normocalcemic PHPT has also been described but clinical consequences are not well established. The biochemical profile of PHPT is characterized by hypercalcemia and high or inappropriately normal PTH concentrations. Parathyroidectomy is the only definitive cure. Medical treatment with the calcimimetic cinacalcet has been shown to normalize calcemia in a high percentage of cases.
原发性甲状旁腺功能亢进症（PHPT）是一种常见的内分泌过程，其特征是血清钙和甲状旁腺激素（PTH）浓度持续升高。多年前，最常见的临床表现形式是有症状的肾脏或骨骼疾病，伴有中重度高钙血症；然而，目前，大多数患者仅有少量症状和轻度高钙血症。另一种新的表现形式，即血钙正常的 PHPT 也已被描述，但临床后果尚未明确。PHPT 的生化特征是高钙血症和高或不适当正常的 PTH 浓度。甲状旁腺切除术是唯一的根治方法。钙敏感受体激动剂西那卡塞的药物治疗已被证明可使很大一部分病例的血钙水平正常化。
