全基因组测序的价格可能在下降，但谁会接受测序呢？
The price of whole-genome sequencing may be decreasing, but who will be sequenced?
作者信息
Marshall Deborah A, MacDonald Karen V, Robinson Jill Oliver, Barcellos Lisa F, Gianfrancesco Milena, Helm Monica, McGuire Amy, Green Robert C, Douglas Michael P, Goldman Michael A, Phillips Kathryn A
机构信息
Department of Community Health Sciences, Room 3C56 Health Research Innovation Centre, University of Calgary, Calgary, Alberta, Canada.
Center for Medical Ethics & Health Policy, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, USA.
出版信息
Per Med. 2017 May;14(3):203-211. doi: 10.2217/pme-2016-0075. Epub 2017 May 23.
AIM
Since whole-genome sequencing (WGS) information can have positive and negative personal utility for individuals, we examined predictors of willingness to pay (WTP) for WGS.
PATIENTS & METHODS: We surveyed two independent populations: adult patients (n = 203) and college seniors (n = 980). Ordinal logistic regression models were used to characterize the relationship between predictors and WTP.
RESULTS
Sex, age, education, income, genomic knowledge and knowing someone who had genetic testing or having had genetic testing done personally were associated with significantly higher WTP for WGS. After controlling for income and education, males were willing to pay more for WGS than females.
CONCLUSION
Differences in WTP may impact equity, coverage, affordability and access, and should be anticipated by public dialog about related health policy.
目的
由于全基因组测序（WGS）信息对个人可能具有正负两方面的个人效用，我们研究了为WGS支付意愿（WTP）的预测因素。
患者与方法
我们对两个独立人群进行了调查：成年患者（n = 203）和大学四年级学生（n = 980）。使用有序逻辑回归模型来描述预测因素与WTP之间的关系。
结果
性别、年龄、教育程度、收入、基因组知识以及认识进行过基因检测的人或个人曾进行过基因检测与为WGS支付意愿显著更高相关。在控制收入和教育程度后，男性为WGS支付的意愿高于女性。
结论
WTP的差异可能会影响公平性、覆盖范围、可承受性和可及性，在有关相关卫生政策的公众对话中应予以考虑。
Zotero 插件