Sastre J, Ibáñez M D, deShazo R D
Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana.
Allergol Immunopathol (Madr). 1988 Mar-Apr;16(2):127-38.
With the increasing number of drugs, the list of agents which are capable of inducing pulmonary reactions continues to lengthen. This article is a compendium of presently available information on drug induced pulmonary reactions which we have found clinically useful. We have divided the drugs in groups on the basis of two features, pharmacologic actions and type of pulmonary reactions. A total of 109 drugs are cited. Categories of pharmacologic actions include cytotoxic drugs, analgesic and antirheumatic drugs, antimicrobial agents, vasoactive drugs, tranquilizers, anticonvulsants, antidepressants, antiarrhythmics, oral antidiabetics and a group of miscellaneous drugs. Type of pulmonary reactions include pulmonary eosinophilia, bronchoconstriction, acute interstitial pulmonary disease, mediastinic involvement, pleural effusion, pulmonary hypertension, pulmonary calcifications, pulmonary infections and drugs reported to cause drug-induced Systemic Lupus Erythematosus.
随着药物数量的不断增加，能够引发肺部反应的药物种类持续增多。本文是我们发现具有临床实用价值的关于药物性肺反应的现有信息汇编。我们根据药理作用和肺部反应类型这两个特征将药物进行了分组。共引用了109种药物。药理作用类别包括细胞毒性药物、止痛和抗风湿药物、抗菌药物、血管活性药物、镇静剂、抗惊厥药、抗抑郁药、抗心律失常药、口服降糖药以及一组杂类药物。肺部反应类型包括肺嗜酸性粒细胞增多症、支气管收缩、急性间质性肺病、纵隔受累、胸腔积液、肺动脉高压、肺钙化、肺部感染以及据报道可引起药物性系统性红斑狼疮的药物。
