情绪障碍在进行多次睡眠潜伏期试验的患者中非常普遍。

Mood disorders are highly prevalent in patients investigated with a multiple sleep latency test.

机构信息

Respiratory Medicine, Alfred Hospital, 55 Commercial Road, Melbourne, 3004, Australia.

Institute for Breathing and Sleep, Austin Hospital, Melbourne, Australia.

出版信息

Sleep Breath. 2018 May;22(2):305-309. doi: 10.1007/s11325-017-1572-8. Epub 2017 Oct 9.

DOI:10.1007/s11325-017-1572-8

PMID:28993975

Abstract

PURPOSE

Excessive daytime sleepiness (EDS) is a debilitating symptom which occurs commonly in both primary sleep and mood disorders. The prevalence of mood disorders in patients with EDS, evaluated objectively with a mean sleep latency test (MSLT), has not been reported. We hypothesize that mood disorders are highly prevalent in patients being investigated for EDS. This study aims to report the prevalence of mood disorder in the MSLT population and investigate the association between mood disorder and objective and subjective scores of sleepiness.

METHODS

A retrospective multicenter study of adults with a MSLT and Hospital Anxiety and Depression Score (HADS) identified over a 3-year period. The HADS is a validated questionnaire in detecting depression (HADS-D ≥ 8) and anxiety (HADS-A ≥ 11) in the sleep clinic population. Data collected included demographics, medical, and sleep study information. Mood disorder prevalence was compared to the general sleep clinic population. Correlation between measures of sleepiness and mood was performed.

RESULTS

Two hundred twenty patients were included with mean age 41.1 ± 15.7 years, mean body mass index 28.6 kg/m of whom 30% had anxiety (HADS-A > 11) and 43% depression (HADS-D > 8). Mean results for the cohort are ESS 13.7, mean sleep latency 11.5 min, HADS-A 8.2, and HADS-D 7. There was no significant correlation between objective sleepiness, as measured by the mean sleep latency, and either HADS-A (-0.006, p = 0.93) or HADS-D score (0.002, p = 0.98). There was, however, a weak correlation between subjective sleepiness, as measured by the ESS, and the mean sleep latency (-0.25, p < 0.01), HADS-A (0.15, p = 0.03), and HADS-D (0.2, p = 0.004). There was no significant association between diagnosis of hypersomnia disorders and presence of anxiety (p = 0.71) or depression (p = 0.83).

CONCLUSIONS

Mood disorders are highly prevalent in the MSLT population. There was a weak correlation found between subjective measures of sleepiness and mood disorders, but not between objective measures of sleepiness and mood disorders. Routine screening for mood disorders in patients with hypersomnolence should be considered.

摘要

目的

日间嗜睡（EDS）是一种常见的原发性睡眠和情绪障碍症状。但目前尚未有研究报告，使用平均睡眠潜伏期测试（MSLT）客观评估时，嗜睡患者中情绪障碍的患病率。我们假设在接受 EDS 检查的患者中，情绪障碍的发生率很高。本研究旨在报告 MSLT 人群中情绪障碍的患病率，并探讨情绪障碍与嗜睡的客观和主观评分之间的关系。

方法

这是一项回顾性多中心研究，纳入了 3 年内接受 MSLT 和医院焦虑抑郁量表（HADS）检查的成年人。HADS 是一种在睡眠诊所人群中检测抑郁（HADS-D≥8）和焦虑（HADS-A≥11）的有效问卷。收集的数据包括人口统计学、医疗和睡眠研究信息。将情绪障碍的患病率与一般睡眠诊所人群进行比较。并分析嗜睡和情绪之间的相关性。

结果

共纳入 220 名平均年龄为 41.1±15.7 岁、平均体重指数为 28.6kg/m²的患者，其中 30%有焦虑（HADS-A＞11），43%有抑郁（HADS-D＞8）。该队列的平均 ESS 为 13.7，平均睡眠潜伏期为 11.5 分钟，HADS-A 为 8.2，HADS-D 为 7.0。客观嗜睡的平均睡眠潜伏期与 HADS-A（-0.006，p=0.93）或 HADS-D 评分（0.002，p=0.98）之间无显著相关性。然而，主观嗜睡的 ESS 与平均睡眠潜伏期（-0.25，p＜0.01）、HADS-A（0.15，p=0.03）和 HADS-D（0.2，p=0.004）之间存在弱相关性。嗜睡障碍的诊断与焦虑（p=0.71）或抑郁（p=0.83）的存在之间无显著关联。