Chaubal Alisha, Pandey Vikas, Choksi Dhaval, Poddar Prateik, Ingle Meghraj, Phadke Aniruddha, Sawant Prabha
Department of Gastroenterology, Lokmanya Tilak Medical College, Dr. Babasaheb Ambedkar Road, Sion West, Mumbai, 400 022, India.
Indian J Gastroenterol. 2017 Sep;36(5):361-365. doi: 10.1007/s12664-017-0791-z. Epub 2017 Oct 9.
Anemia is common in patients with active ulcerative colitis. We aimed to study the anemia profile in patients with ulcerative colitis in clinical remission.
Sixty-four patients with ulcerative colitis and with a clinical Mayo score less than 3 for at least 3 months were evaluated for anemia. Initial screening was done by hemogram and only patients with anemia were evaluated further for the cause of anemia. We also screened a control population for anemia. Patients with mild anemia were given oral iron, moderate anemia were given intravenous iron and severe anemia were given blood transfusion.
The mean hemoglobin in ulcerative colitis patients was 11.75 g/dL and in controls was 13.1 g/dL (p=0.011). The prevalence of anemia was 53.1% in the ulcerative colitis patients and 13.3% in the controls (p=<0.001). 58.8% had mild anemia, 29.4% had moderate anemia and 8.8% had severe anemia. Iron deficiency was the most common cause of anemia (70.5%) followed by anemia of chronic disease combined with iron deficiency in 23.5%. Ferritin levels did not correlate with hemoglobin levels. Oral iron increased the hemoglobin by 1.4 g/dL and intravenous iron by 2.2 g/dL at 1 month.
Anemia was seen in more than half of patients with ulcerative colitis in clinical remission, iron deficiency being the most common cause.
贫血在活动性溃疡性结肠炎患者中很常见。我们旨在研究临床缓解期溃疡性结肠炎患者的贫血情况。
对64例溃疡性结肠炎患者进行评估，这些患者的临床梅奥评分至少3个月低于3分，评估其是否贫血。最初通过血常规进行筛查，仅对贫血患者进一步评估贫血原因。我们还对对照组人群进行贫血筛查。轻度贫血患者给予口服铁剂，中度贫血患者给予静脉铁剂，重度贫血患者给予输血治疗。
溃疡性结肠炎患者的平均血红蛋白为11.75 g/dL，对照组为13.1 g/dL（p = 0.011）。溃疡性结肠炎患者的贫血患病率为53.1%，对照组为13.3%（p < 0.001）。58.8%为轻度贫血，29.4%为中度贫血，8.8%为重度贫血。缺铁是贫血最常见的原因（70.5%），其次是慢性病贫血合并缺铁，占23.5%。铁蛋白水平与血红蛋白水平无关。口服铁剂在1个月时使血红蛋白升高1.4 g/dL，静脉铁剂使血红蛋白升高2.2 g/dL。
超过一半的临床缓解期溃疡性结肠炎患者存在贫血，缺铁是最常见的原因。
