斯堪的纳维亚半岛炎症性肠病门诊患者贫血和缺铁的患病率。

The prevalence of anemia and iron deficiency in IBD outpatients in Scandinavia.

作者信息

Bager Palle, Befrits Ragnar, Wikman Ola, Lindgren Stefan, Moum Bjørn, Hjortswang Henrik, Dahlerup Jens F

机构信息

Department of Medicine V (Hepatology and Gastroenterology), Aarhus University Hospital, Denmark.

出版信息

Scand J Gastroenterol. 2011 Mar;46(3):304-9. doi: 10.3109/00365521.2010.533382. Epub 2010 Nov 15.

DOI:10.3109/00365521.2010.533382

PMID:21073374

Abstract

OBJECTIVE

To evaluate the prevalence of anemia and iron deficiency (ID) among patients with inflammatory bowel disease (IBD) in the Scandinavian countries.

MATERIAL AND METHODS

A cross-sectional study including 429 IBD patients from six centers in Denmark, Norway and Sweden. Patients were screened for anemia and ID. Each center included ~5% of their IBD cohort. Patients were consecutively seen in the outpatient clinic, regardless of disease activity and whether the visits were scheduled or not.

RESULTS

The overall prevalence of anemia was 19% (95% CI: 16-23%). The prevalence was higher among patients with Crohn's disease than among patients with ulcerative colitis (p = 0.01). The etiology of anemia was as follows: iron deficiency anemia (20%), anemia of chronic disease (12%), and both conditions (68%). Less than 5% had folate acid or vitamin B12 deficiency. ID was found in 35% (CI: 31-40%) of the patients.

CONCLUSIONS

Anemia was present in every fifth IBD patient and ID in every third IBD patient.

摘要

目的

评估斯堪的纳维亚国家炎症性肠病（IBD）患者中贫血和缺铁（ID）的患病率。

材料与方法

一项横断面研究，纳入了来自丹麦、挪威和瑞典六个中心的429例IBD患者。对患者进行贫血和ID筛查。每个中心纳入其IBD队列的约5%。患者在门诊连续就诊，无论疾病活动情况以及就诊是否预约。

结果

贫血的总体患病率为19%（95%可信区间：16 - 23%）。克罗恩病患者的患病率高于溃疡性结肠炎患者（p = 0.01）。贫血的病因如下：缺铁性贫血（20%）、慢性病贫血（12%）以及两种情况并存（68%）。叶酸或维生素B12缺乏的患者不到5%。35%（可信区间：31 - 40%）的患者存在ID。