Bager Palle, Befrits Ragnar, Wikman Ola, Lindgren Stefan, Moum Bjørn, Hjortswang Henrik, Dahlerup Jens F
Department of Medicine V (Hepatology and Gastroenterology), Aarhus University Hospital, Denmark.
Scand J Gastroenterol. 2011 Mar;46(3):304-9. doi: 10.3109/00365521.2010.533382. Epub 2010 Nov 15.
To evaluate the prevalence of anemia and iron deficiency (ID) among patients with inflammatory bowel disease (IBD) in the Scandinavian countries.
A cross-sectional study including 429 IBD patients from six centers in Denmark, Norway and Sweden. Patients were screened for anemia and ID. Each center included ~5% of their IBD cohort. Patients were consecutively seen in the outpatient clinic, regardless of disease activity and whether the visits were scheduled or not.
The overall prevalence of anemia was 19% (95% CI: 16-23%). The prevalence was higher among patients with Crohn's disease than among patients with ulcerative colitis (p = 0.01). The etiology of anemia was as follows: iron deficiency anemia (20%), anemia of chronic disease (12%), and both conditions (68%). Less than 5% had folate acid or vitamin B12 deficiency. ID was found in 35% (CI: 31-40%) of the patients.
Anemia was present in every fifth IBD patient and ID in every third IBD patient.
评估斯堪的纳维亚国家炎症性肠病（IBD）患者中贫血和缺铁（ID）的患病率。
一项横断面研究，纳入了来自丹麦、挪威和瑞典六个中心的429例IBD患者。对患者进行贫血和ID筛查。每个中心纳入其IBD队列的约5%。患者在门诊连续就诊，无论疾病活动情况以及就诊是否预约。
贫血的总体患病率为19%（95%可信区间：16 - 23%）。克罗恩病患者的患病率高于溃疡性结肠炎患者（p = 0.01）。贫血的病因如下：缺铁性贫血（20%）、慢性病贫血（12%）以及两种情况并存（68%）。叶酸或维生素B12缺乏的患者不到5%。35%（可信区间：31 - 40%）的患者存在ID。
每五分之一的IBD患者存在贫血，每三分之一的IBD患者存在ID。
