EaStCHEM School of Chemistry, University of St Andrews, Fife KY16 9ST, UK.
Molecules. 2017 Oct 10;22(10):1687. doi: 10.3390/molecules22101687.
A new one-pot preparative route was developed to synthesize novel organophosphorus-sulfur heterocycles via the reaction of the four-membered ring thionation reagent [2,4-diferrocenyl-1,3,2,4-diathiadiphosphetane 2,4-disulfide (FcLR, a ferrocene analogue of Lawesson's reagent)] and alkenyl/aryl-diols and I₂ (or SOCl₂) in the presence of triethylamine. Therefore, a series of five- to ten-membered heterocycles bearing an O-P(S)-O or an O-P(S)-S-S-P(S)-O linkage were synthesized. The synthesis features a novel application of the multicomponent reaction, providing an efficient and environmentally benign method for the preparation of the unusual phosphorus-sulfur heterocycles. Seven representative X-ray structures confirm the formation of these heterocycles.
开发了一种新的一锅法制备路线，通过四元环硫代试剂[2,4-二（二茂铁基）-1,3,2,4-二噻二磷杂戊环 2,4-二硫化物（FcLR，劳森试剂的二茂铁类似物）]与烯基/芳基-二醇和 I₂（或 SOCl₂）在三乙胺存在下的反应，合成了一系列含有 O-P(S)-O 或 O-P(S)-S-S-P(S)-O 键的五至十个杂环。该合成方法具有多组分反应的新颖应用，为制备不寻常的磷硫杂环提供了一种高效且环境友好的方法。七个代表性的 X 射线结构证实了这些杂环的形成。
