2-(3-氟-4-羟基苯基)乙胺及其N-烷基衍生物的合成与多巴胺受体结合亲和力
Synthesis and dopamine receptors binding affinity of 2-(3-fluoro-4-hydroxyphenyl)ethylamine and its N-alkyl derivatives.
作者信息
Cardellini M, Cingolani G M, Claudi F, Perlini V, Balduini W, Cattabeni F
机构信息
Dipartimento di Scienze Chimiche, Università di Camerino, Italy.
出版信息
Farmaco Sci. 1988 Jan;43(1):49-59.
PMID:2899520
Abstract
The 2-(3-fluoro-4-hydroxyphenyl)ethylamine and its N,N-dialkyl derivatives were synthesized. The affinity of new compounds for dopamine binding sites was measured in a test involving displacement of [3H]SCH 23390 (D-1 selective) and [3H]spiperone (D-2 selective) from homogenized rat striatal tissue. No compound proved effective in displacing [3H]SCH 23390. Two derivatives are selective displacers of [3H]spiperone.
摘要
合成了2-(3-氟-4-羟基苯基)乙胺及其N,N-二烷基衍生物。在一项涉及从匀浆大鼠纹状体组织中置换[3H]SCH 23390（D-1选择性）和[3H]螺哌隆（D-2选择性）的试验中，测定了新化合物对多巴胺结合位点的亲和力。没有化合物被证明能有效置换[3H]SCH 23390。两种衍生物是[3H]螺哌隆的选择性置换剂。
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