Hu C Y, Suryawan A, Forsberg N E, Dalrymple R H, Ricks C A
Dept. of Anim. Sci., Oregon State University, Corvallis 97331.
J Anim Sci. 1988 Jun;66(6):1393-400. doi: 10.2527/jas1988.6661393x.
Effects of dietary cimaterol (5 mg/kg) on adipose tissue metabolism of wether lambs were studied. Lipogenesis, lipolysis, fatty acid composition and adipocyte size and number were measured. Cimaterol feeding increased lipogenesis; however, this effect was not statistically significant. Insulin (1,000 microU/ml) stimulated lipogenesis of adipose tissue from control sheep. However, this elevated rate was abolished by in vitro cimaterol. Insulin had no stimulatory effect on lipogenesis in cimaterol-fed sheep. Lipolysis was depressed by cimaterol feeding. However, 10(-4) M cimaterol stimulated lipolysis in the adipose tissue from both control and cimaterol-fed sheep. Insulin inhibited stimulated lipolysis in adipose tissue from control sheep but had no effect on the stimulated lipolysis in cimaterol-fed sheep. Mean adipocyte diameter was smaller (from 74 to 70 microns) and adipocyte size distribution also was changed in the cimaterol-fed sheep. Adipocyte number per gram of tissue was not affected by cimaterol. There was a significant increase in percentage of unsaturated fatty acids in adipose tissue from cimaterol-fed sheep. These results indicate that lipogenic and lipolytic responses to insulin and cimaterol in sheep adipose tissue were altered by cimaterol feeding. The carcass fat content decrease in cimaterol-fed sheep may be attributed to the reduction in adipocyte size.
研究了日粮中添加西马特罗（5毫克/千克）对去势羔羊脂肪组织代谢的影响。测定了脂肪生成、脂肪分解、脂肪酸组成以及脂肪细胞大小和数量。饲喂西马特罗可增加脂肪生成；然而，这种影响在统计学上并不显著。胰岛素（1000微单位/毫升）刺激了对照绵羊脂肪组织的脂肪生成。然而，体外添加西马特罗消除了这种升高的速率。胰岛素对饲喂西马特罗的绵羊的脂肪生成没有刺激作用。饲喂西马特罗可抑制脂肪分解。然而，10⁻⁴摩尔/升的西马特罗刺激了对照绵羊和饲喂西马特罗的绵羊的脂肪组织中的脂肪分解。胰岛素抑制了对照绵羊脂肪组织中刺激的脂肪分解，但对饲喂西马特罗的绵羊中刺激的脂肪分解没有影响。饲喂西马特罗的绵羊的平均脂肪细胞直径较小（从74微米降至70微米），且脂肪细胞大小分布也发生了变化。每克组织中的脂肪细胞数量不受西马特罗的影响。饲喂西马特罗的绵羊的脂肪组织中不饱和脂肪酸的百分比显著增加。这些结果表明，饲喂西马特罗改变了绵羊脂肪组织对胰岛素和西马特罗的脂肪生成和脂肪分解反应。饲喂西马特罗的绵羊胴体脂肪含量降低可能归因于脂肪细胞大小的减小。
