Scott J, Higenbottam T, Hutter J, Hodson M, Stewart S, Penketh A, Wallwork J
Heart-lung Transplant Unit, Papworth Hospital, Cambridge.
Lancet. 1988 Jul 23;2(8604):192-4. doi: 10.1016/s0140-6736(88)92290-8.
13 patients with severe lung disease and cor pulmonale from cystic fibrosis were accepted for heart-lung transplantation (HLT). 6 have had the operation, of whom 5 are well, with normal lung function, 3-29 months after operation. 1 patient died from adult respiratory distress syndrome after reoperation to control persistent chest-wall bleeding: at necropsy, this patient proved to have cirrhosis. Respiratory tract infections and acute lung rejection after HLT for cystic fibrosis were no more common than in other HLT patients. Of the 7 patients for whom suitable donor organs were not found, 3 died within 3 months of assessment. Initial severity of disease had been similar to that in the transplant group. The cost of assessment, operation, and 1 year's treatment after HLT is similar to that of medical treatment for such patients.
13名患有囊性纤维化所致严重肺部疾病和肺心病的患者接受了心肺移植（HLT）。6名患者已接受手术，其中5名术后3至29个月情况良好，肺功能正常。1名患者在再次手术以控制持续胸壁出血后死于成人呼吸窘迫综合征：尸检时，该患者被证实患有肝硬化。囊性纤维化患者接受HLT后的呼吸道感染和急性肺排斥反应并不比其他HLT患者更常见。在7名未找到合适供体器官的患者中，3名在评估后3个月内死亡。疾病的初始严重程度与移植组相似。HLT术后评估、手术及1年治疗的费用与这类患者的药物治疗费用相似。
