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纹状体中多巴胺能传递的突触前调节。

Presynaptic regulation of dopaminergic transmission in the striatum.

作者信息

Glowinski J, Chéramy A, Romo R, Barbeito L

机构信息

INSERM U.114, Collège de France, Paris.

出版信息

Cell Mol Neurobiol. 1988 Mar;8(1):7-17. doi: 10.1007/BF00712906.

Abstract
  1. In vitro studies have indicated that several transmitters present in the striatum can regulate presynaptically the release of dopamine (DA) from nerve terminals of the nigrostriatal DA neurons. 2. The receptors involved in these local regulatory processes are located or not located on DA nerve terminals. 3. Recent in vivo investigations have demonstrated that the corticostriatal glutamatergic neurons facilitate presynaptically the release of DA and have allowed the analysis of the respective roles of presynaptic events and nerve activity in the control of DA transmission.
摘要
  1. 体外研究表明,纹状体内存在的几种递质可在突触前调节黑质纹状体多巴胺(DA)神经元神经末梢释放DA。2. 参与这些局部调节过程的受体位于或不位于DA神经末梢上。3. 最近的体内研究表明,皮质纹状体谷氨酸能神经元在突触前促进DA的释放,并使得对突触前事件和神经活动在DA传递控制中的各自作用进行分析成为可能。

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Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices.
Neurosci Lett. 1977 Oct;6(1):73-7. doi: 10.1016/0304-3940(77)90068-4.

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