生长抑素类似物在胃肠道肿瘤治疗中的应用

Somatostatin analogs in the management of gastrointestinal tumors.

作者信息

Lamberts S W

机构信息

Department of Medicine, Erasmus University, Rotterdam, The Netherlands.

出版信息

Horm Res. 1988;29(2-3):118-20. doi: 10.1159/000180985.

DOI:10.1159/000180985

PMID:2900191

Abstract

Experience with SMS 201-995 (Sandostatin), a somatostatin analog, in the treatment of endocrine active gastrointestinal tumors is reviewed. Best immediate results were obtained in vipomas and insulinomas but a scape phenomenon was frequently observed. A positive and persistent effect was recorded in a case of nesidioblastosis. It was striking that good clinical control could be obtained in some instances despite insufficient suppression of hormone secretion by the tumor. This finding suggests peripheral actions of somatostatin and SMS independently of its primary effect on hormone release.

摘要

回顾了生长抑素类似物SMS 201-995（善得定）治疗内分泌活性胃肠道肿瘤的经验。在血管活性肠肽瘤和胰岛素瘤中取得了最佳的即时效果，但经常观察到逃逸现象。在胰岛细胞增殖症的一例中记录到了积极且持久的效果。令人惊讶的是，尽管肿瘤对激素分泌的抑制不足，但在某些情况下仍能获得良好的临床控制。这一发现表明生长抑素和SMS具有独立于其对激素释放的主要作用的外周作用。