Holmes R, Hagler H
Division of Plastic Surgery, University of California, San Diego.
J Craniomaxillofac Surg. 1988 Jul;16(5):199-205. doi: 10.1016/s1010-5182(88)80047-7.
A porous HA matrix, which is available for clinical use, was compared with split rib autografts after maxillary contour augmentation in 17 dogs. Specimens were retrieved at 3, 6, 12, 24 and 48 months and undecalcified sections were prepared for microscopy and histometry. The implant and graft cross sectional areas did not change with time, although mechanical trauma caused early changes in implant area in some specimens. In all implants, union with the maxillary cortex occurred along with substantial bone ingrowth. An area under the periosteum contained soft tissue ingrowth. In all grafts, except one, union also occurred. However, bone ingrowth into the cancellous spaces was not apparent, or minimal. The implant specimens were composed of 34.7% HA matrix, 23.9% bone and 41.3% soft tissue. The bone ingrowth remained permanent for the study duration. A 6.5% decrease in HA matrix occurred between the 24 and 48 month time intervals, suggesting the presence of microporous surface resorption. The graft specimens were composed of 55.8% bone and 44.2% non-mineralized tissue, without change over time. The similarity in mineralized tissue composition of the implants (58.6%) and grafts (55.8%) supported the thesis that a porous HA matrix can function as a bone graft substitute.
将一种可供临床使用的多孔羟基磷灰石（HA）基质与17只犬上颌轮廓增大术后的自体肋骨劈开移植骨进行比较。在3、6、12、24和48个月时取出标本，制备不脱钙切片用于显微镜检查和组织测量。尽管机械创伤在一些标本中导致植入物面积早期变化，但植入物和移植骨的横截面积并未随时间改变。在所有植入物中，与上颌皮质的结合伴随着大量骨长入发生。骨膜下区域有软组织长入。在所有移植骨中，除一块外，也发生了结合。然而，松质骨间隙中的骨长入不明显或极少。植入物标本由34.7%的HA基质、23.9%的骨和41.3%的软组织组成。在研究期间，骨长入保持持久。在24至48个月的时间间隔内，HA基质减少了6.5%，表明存在微孔表面吸收。移植骨标本由55.8%的骨和44.2%的非矿化组织组成，且随时间无变化。植入物（58.6%）和移植骨（55.8%）矿化组织组成的相似性支持了多孔HA基质可作为骨移植替代物的论点。
