扎考必利，一种强效的5-羟色胺3拮抗剂。
Zacopride, a potent 5-HT3 antagonist.
作者信息
Smith W W, Sancilio L F, Owera-Atepo J B, Naylor R J, Lambert L
机构信息
Department of Pharmacology, A. H. Robins Co., Richmond, VA 23220.
出版信息
J Pharm Pharmacol. 1988 Apr;40(4):301-2. doi: 10.1111/j.2042-7158.1988.tb05253.x.
Abstract
The substituted benzamide derivative zacopride was found to antagonize competitively the effects of 5-hydroxytryptamine (5-HT) on the guinea-pig ileum, the rabbit vagus nerve and the von Bezold Jarisch reflex in the rat. The potency of zacopride was comparable with that of ICS 205-930 and it is concluded that zacopride possesses 5-HT3 receptor antagonizing properties.
摘要
已发现取代苯甲酰胺衍生物扎考必利能竞争性拮抗5-羟色胺（5-HT）对豚鼠回肠、兔迷走神经及大鼠贝佐尔德-雅里什反射的作用。扎考必利的效价与ICS 205-930相当，由此得出结论，扎考必利具有5-HT3受体拮抗特性。
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