Butturini A, De Souza P C, Gale R P, Cordiero J M, Lopes D M, Neto C, Cunha C B, De Souza C E, Ho W G, Tabak D G
Hospital Marcilio Dias, Rio de Janeiro, Brazil.
Lancet. 1988 Aug 27;2(8609):471-5. doi: 10.1016/s0140-6736(88)90121-3.
8 patients with bone marrow failure after a caesium-137 radiation accident were treated with recombinant human granulocyte-macrophage colony stimulating factor (rHuGM-CSF). The 7 who were evaluable had prompt increases in granulocytes and bone marrow cellularity. 2 patients died of radiation toxicity and haemorrhage and 2 of bacterial sepsis acquired before the start of rHuGM-CSF treatment. 4 patients survive, including 2 who were treated early and never became infected. This therapeutic approach to radiation-induced granulocytopenia may therefore be useful after radiation and nuclear accidents.
8例铯-137辐射事故后发生骨髓衰竭的患者接受了重组人粒细胞-巨噬细胞集落刺激因子（rHuGM-CSF）治疗。7例可评估患者的粒细胞和骨髓细胞数量迅速增加。2例患者死于放射毒性和出血，2例死于rHuGM-CSF治疗开始前获得的细菌性败血症。4例患者存活，其中2例早期接受治疗且未发生感染。因此，这种治疗放射性粒细胞减少症的方法在辐射和核事故后可能有用。
