Layton M W, Fudman E J, Barkan A, Braunstein E M, Fox I H
Rackham Arthritis Research Unit, Department of Internal Medicine, University Hospital, Ann Arbor, Michigan 48109-0108.
Arthritis Rheum. 1988 Aug;31(8):1022-7. doi: 10.1002/art.1780310813.
Arthropathy was assessed in 19 patients with active acromegaly. Axial or peripheral arthropathy was present in 10 patients, was located most often in large joints or the lumbosacral spine, and was osteoarthritic in nature. The mean duration of acromegaly in patients with arthropathy was 21.6 years, while the mean duration in patients without arthropathy was 7.9 years. A mild-to-moderate improvement in symptoms, estimated functional ability, and crepitus occurred in 8 of 9 patients who were prospectively examined during therapy to lower production of growth hormone. We conclude that this therapy did improve the symptoms of acromegalic arthropathy. Whether objective structural improvements occur remains unclear.
对19例活动性肢端肥大症患者的关节病进行了评估。10例患者存在轴向或周围关节病，最常位于大关节或腰骶椎，本质上为骨关节炎。有关节病的患者肢端肥大症的平均病程为21.6年，而无关节病的患者平均病程为7.9年。在治疗期间前瞻性检查的9例旨在降低生长激素分泌的患者中，有8例患者的症状、估计功能能力和摩擦音有轻度至中度改善。我们得出结论，这种治疗确实改善了肢端肥大症性关节病的症状。客观结构改善是否发生尚不清楚。
