分裂情感性躁狂症、躁狂症和精神分裂症中的促甲状腺激素释放激素试验及地塞米松抑制试验
TRH test and DST in schizoaffective mania, mania, and schizophrenia.
作者信息
Kiriike N, Izumiya Y, Nishiwaki S, Maeda Y, Nagata T, Kawakita Y
机构信息
Department of Neuropsychiatry, Osaka City University Medical School, Japan.
出版信息
Biol Psychiatry. 1988 Aug;24(4):415-22. doi: 10.1016/0006-3223(88)90178-3.
The thyrotropin-releasing hormone (TRH) test and the Dexamethasone Suppression Test (DST) were given to 10 patients who met Research Diagnostic Criteria (RDC) for schizoaffective disorder, manic type, 9 who met the criteria for mania, and 27 who met the criteria for schizophrenia. A blunted thyrotropin (TSH) response to TRH was observed in 3 of the 10 schizoaffective manics, 4 of the 9 manics, and 3 of the 27 schizophrenics. Nonsuppression on the DST was observed in 5 of the 10 schizoaffective manics, 2 of the 9 manics, and 2 of 22 schizophrenics. The schizoaffective manic and the manic patients had similar rates of TSH blunting and DST nonsuppression, and these were significantly higher than the rates in the schizophrenic patients. This difference was not attributable to baseline TSH and cortisol levels or to neuroleptic treatment. It is suggested that patients with RDC schizoaffective mania and mania have more disturbance in the hypothalamic-pituitary adrenal and thyroid axes than patients with schizophrenia.
对10名符合分裂情感性障碍躁狂型研究诊断标准（RDC）的患者、9名符合躁狂症标准的患者以及27名符合精神分裂症标准的患者进行了促甲状腺激素释放激素（TRH）试验和地塞米松抑制试验（DST）。在10名分裂情感性躁狂症患者中有3名、9名躁狂症患者中有4名以及27名精神分裂症患者中有3名观察到促甲状腺激素（TSH）对TRH的反应迟钝。在10名分裂情感性躁狂症患者中有5名、9名躁狂症患者中有2名以及22名精神分裂症患者中有2名观察到DST结果未被抑制。分裂情感性躁狂症患者和躁狂症患者的TSH反应迟钝率和DST未被抑制率相似，且这些比率显著高于精神分裂症患者中的比率。这种差异并非归因于基线TSH和皮质醇水平或抗精神病药物治疗。提示符合RDC的分裂情感性躁狂症患者和躁狂症患者相比精神分裂症患者，下丘脑 - 垂体 - 肾上腺和甲状腺轴存在更多紊乱。
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