Neural control of blood glucose homeostasis; effect of microinjection of glucose into hypothalamic nuclei on efferent activity of pancreatic branch of vagus nerve in the rat.

Efferent discharges were recorded from the nerve filament dissected from the central cut end of the pancreatic branch of the vagus nerve in the rat. Microinjections of 5% glucose solution (100-200 nl) into the LHA caused an increase in efferent activity, however, those into VMH caused no change in discharge rate. The results of experiments indicate that activation of vagal pancreatic efferents in hyperglycemic situation is originated in LHA and transmitted to the vagal pancreatic motoneurons. The role played by the neural network on blood glucose homeostasis was also discussed.