Devanand D P, Sackeim H A, Mayeux R
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, NY.
Compr Psychiatry. 1988 Jul-Aug;29(4):387-401. doi: 10.1016/0010-440x(88)90020-x.
Despite the widespread use of psychotropic agents in patients with dementia, there is little available research on the nature and prevalence of psychiatric disturbance and behavioral syndromes requiring this treatment, and the results of such therapy. The authors suggest strategies to overcome difficulties inherent in attempting to obtain symptom profiles in demented patients. There is weak evidence to support the use of neuroleptics in the treatment of symptoms like suspiciousness, hallucinations, sleeplessness, agitation, emotional liability, and aggressiveness; no individual neuroleptic can be considered superior to any other for this purpose. Few studies have evaluated the effect of neuroleptics on activities of daily life (ADL), and no study has used detailed neurophsychological evaluation to examine their effects on cognitive function in dementia.
尽管精神药物在痴呆患者中广泛使用，但关于需要这种治疗的精神障碍和行为综合征的性质、患病率以及此类治疗的结果，现有研究很少。作者提出了一些策略，以克服在试图获取痴呆患者症状概况时所固有的困难。支持使用抗精神病药物治疗如怀疑、幻觉、失眠、激越、情绪不稳定和攻击性等症状的证据不足；在此方面，没有哪种抗精神病药物可被认为比其他药物更具优势。很少有研究评估抗精神病药物对日常生活活动（ADL）的影响，也没有研究使用详细的神经心理学评估来检查它们对痴呆患者认知功能的影响。
