神经母细胞瘤中人类N-myc癌基因的扩增等位基因。

Amplified allele of the human N-myc oncogene in neuroblastomas.

作者信息

Yamada M, Kurosawa H, Nakagawa Y, Nakagome Y, Tsuda T, Higashi K

机构信息

National Children's Medical Research Center, Tokyo.

出版信息

Jpn J Cancer Res. 1988 Jun;79(6):670-3. doi: 10.1111/j.1349-7006.1988.tb02219.x.

DOI:10.1111/j.1349-7006.1988.tb02219.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5917576/

Abstract

The N-myc amplification unit was investigated using two restriction fragment length polymorphisms for SphI and PvuII which we previously found to occur in the 2nd intron and in the 3' region of the human N-myc oncogene, respectively. All the three haplotypes which are dominant in the Japanese population were observed in the amplified DNA after analyses of a total of 22 DNA samples of fresh neuroblastomas with N-myc amplification. We conclude that only one of the alleles was amplified and that either allele could be amplified with respect to both the SphI and PvuII polymorphisms.

摘要

利用两种限制性片段长度多态性对N - myc扩增单位进行了研究，这两种多态性分别是针对SphI和PvuII的，我们之前发现它们分别出现在人N - myc癌基因的第2内含子和3'区域。在对总共22个具有N - myc扩增的新鲜神经母细胞瘤DNA样本进行分析后，在扩增的DNA中观察到了在日本人群中占主导地位的所有三种单倍型。我们得出结论，只有一个等位基因被扩增，并且就SphI和PvuII多态性而言，任何一个等位基因都可能被扩增。

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Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour.人类神经母细胞瘤细胞系和一个神经母细胞瘤肿瘤中存在与myc细胞癌基因同源性有限的扩增DNA。

Nature. 1983;305(5931):245-8. doi: 10.1038/305245a0.

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Expression and amplification of the N-myc gene in primary retinoblastoma.N-myc基因在原发性视网膜母细胞瘤中的表达与扩增

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Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage.未经治疗的人类神经母细胞瘤中N - myc的扩增与疾病晚期相关。

Science. 1984 Jun 8;224(4653):1121-4. doi: 10.1126/science.6719137.

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Gene amplification.基因扩增

Annu Rev Biochem. 1984;53:447-91. doi: 10.1146/annurev.bi.53.070184.002311.

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Construction of a genetic linkage map in man using restriction fragment length polymorphisms.利用限制性片段长度多态性构建人类遗传连锁图谱。

Am J Hum Genet. 1980 May;32(3):314-31.

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Transposition and amplification of oncogene-related sequences in human neuroblastomas.人类神经母细胞瘤中癌基因相关序列的转位与扩增。

Cell. 1983 Dec;35(2 Pt 1):359-67. doi: 10.1016/0092-8674(83)90169-1.

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