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1
Amplified allele of the human N-myc oncogene in neuroblastomas.神经母细胞瘤中人类N-myc癌基因的扩增等位基因。
Jpn J Cancer Res. 1988 Jun;79(6):670-3. doi: 10.1111/j.1349-7006.1988.tb02219.x.
2
Restriction fragment length polymorphisms of the human N-myc gene: relationship to gene amplification.人类N-myc基因的限制性片段长度多态性：与基因扩增的关系
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3
Preferential amplification of the paternal allele in neuroblastomas with N-myc amplification.在伴有N-myc扩增的神经母细胞瘤中父本等位基因的优先扩增。
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4
Nonrandom distribution of N-myc oncogene genotypes in neuroblastoma.神经母细胞瘤中N - myc癌基因基因型的非随机分布。
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Preferential amplification of the paternal allele of the N-myc gene in human neuroblastomas.人类神经母细胞瘤中N - myc基因父本等位基因的优先扩增。
Nat Genet. 1993 Jun;4(2):191-4. doi: 10.1038/ng0693-191.
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Restriction fragment length polymorphisms of the human N-myc gene in normal healthy individuals and oral cancer patients in India.印度正常健康个体和口腔癌患者中人类N-myc基因的限制性片段长度多态性
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Allelic loss of chromosome 1p36 in neuroblastoma is of preferential maternal origin and correlates with N-myc amplification.神经母细胞瘤中1p36染色体的等位基因缺失优先源自母系，且与N-myc扩增相关。
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Transposition and amplification of oncogene-related sequences in human neuroblastomas.人类神经母细胞瘤中癌基因相关序列的转位与扩增。
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10
Amplification units containing human N-myc and c-myc genes.包含人类N-myc和c-myc基因的扩增单位。
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Somatic genomic alterations in retinoblastoma beyond RB1 are rare and limited to copy number changes.视网膜母细胞瘤中除RB1基因外的体细胞基因组改变很少见，且仅限于拷贝数变化。
Sci Rep. 2016 Apr 29;6:25264. doi: 10.1038/srep25264.

本文引用的文献

1
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour.人类神经母细胞瘤细胞系和一个神经母细胞瘤肿瘤中存在与myc细胞癌基因同源性有限的扩增DNA。
Nature. 1983;305(5931):245-8. doi: 10.1038/305245a0.
2
Expression and amplification of the N-myc gene in primary retinoblastoma.N-myc基因在原发性视网膜母细胞瘤中的表达与扩增
Nature. 1984;309(5967):458-60. doi: 10.1038/309458a0.
3
Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage.未经治疗的人类神经母细胞瘤中N - myc的扩增与疾病晚期相关。
Science. 1984 Jun 8;224(4653):1121-4. doi: 10.1126/science.6719137.
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Gene amplification.基因扩增
Annu Rev Biochem. 1984;53:447-91. doi: 10.1146/annurev.bi.53.070184.002311.
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Construction of a genetic linkage map in man using restriction fragment length polymorphisms.利用限制性片段长度多态性构建人类遗传连锁图谱。
Am J Hum Genet. 1980 May;32(3):314-31.
6
Transposition and amplification of oncogene-related sequences in human neuroblastomas.人类神经母细胞瘤中癌基因相关序列的转位与扩增。
Cell. 1983 Dec;35(2 Pt 1):359-67. doi: 10.1016/0092-8674(83)90169-1.
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Selective amplification of polymorphic dihydrofolate reductase gene loci in Chinese hamster lung cells.中国仓鼠肺细胞中多态性二氢叶酸还原酶基因位点的选择性扩增
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8
Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas.N - myc 癌基因的多个拷贝与神经母细胞瘤的快速进展之间的关联。
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9
Analysis of N-myc amplification in relation to disease stage and histologic types in human neuroblastomas.人类神经母细胞瘤中N-myc扩增与疾病分期及组织学类型的关系分析。
Cancer. 1987 Aug 15;60(4):820-6. doi: 10.1002/1097-0142(19870815)60:4<820::aid-cncr2820600418>3.0.co;2-y.
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Ha-ras hypervariable alleles in myelodysplasia.骨髓增生异常综合征中的Ha-ras高变等位基因
Nature. 1986;321(6065):84-5. doi: 10.1038/321084a0.

神经母细胞瘤中人类N-myc癌基因的扩增等位基因。

Amplified allele of the human N-myc oncogene in neuroblastomas.

作者信息

Yamada M, Kurosawa H, Nakagawa Y, Nakagome Y, Tsuda T, Higashi K

机构信息

National Children's Medical Research Center, Tokyo.

出版信息

Jpn J Cancer Res. 1988 Jun;79(6):670-3. doi: 10.1111/j.1349-7006.1988.tb02219.x.

DOI:10.1111/j.1349-7006.1988.tb02219.x
PMID:2900826
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5917576/
Abstract

The N-myc amplification unit was investigated using two restriction fragment length polymorphisms for SphI and PvuII which we previously found to occur in the 2nd intron and in the 3' region of the human N-myc oncogene, respectively. All the three haplotypes which are dominant in the Japanese population were observed in the amplified DNA after analyses of a total of 22 DNA samples of fresh neuroblastomas with N-myc amplification. We conclude that only one of the alleles was amplified and that either allele could be amplified with respect to both the SphI and PvuII polymorphisms.

摘要

利用两种限制性片段长度多态性对N - myc扩增单位进行了研究，这两种多态性分别是针对SphI和PvuII的，我们之前发现它们分别出现在人N - myc癌基因的第2内含子和3'区域。在对总共22个具有N - myc扩增的新鲜神经母细胞瘤DNA样本进行分析后，在扩增的DNA中观察到了在日本人群中占主导地位的所有三种单倍型。我们得出结论，只有一个等位基因被扩增，并且就SphI和PvuII多态性而言，任何一个等位基因都可能被扩增。