Scheid W, Weber J, Traut H
Institut für Strahlenbiologie, Universität Münster, F.R.G.
Int J Radiat Biol. 1988 Sep;54(3):395-402. doi: 10.1080/09553008814551781.
After occupational and medical radiation exposures structural chromosome aberrations may be induced in the lymphocytes of the irradiated persons. Many authors have estimated the radiation dose from the yields of dicentric aberrations. We analysed the influence on the dicentric yield of increasing time intervals between irradiation and blood sampling from a person involved in an X-radiation accident (radiography). During a 4-year follow-up we observed an approximately 7-fold decline of the dicentric yield up to the 25th month and thereafter an almost constant value. Since the decline did not commence until around the 10th month after the exposure, an exponential decrease of dicentric yield with time should be considered with reservation in this study, although it cannot be entirely ruled out. We conclude that in 'biological dosimetry' blood should be sampled as early as possible after the exposure. Furthermore, computation of 'half-times' of lymphocytes to allow for a delay in blood sampling seems uncertain after partial body exposures to high doses. Therefore in such cases dose estimates obtained 1 or more years after irradiation should be considered as minimum values.
职业性和医疗性辐射暴露后，受照者淋巴细胞中可能会诱发染色体结构畸变。许多作者已根据双着丝粒畸变的产额估算辐射剂量。我们分析了对于一名受X射线辐射事故（X线摄影）影响的人员，增加照射与采血之间的时间间隔对双着丝粒产额的影响。在4年的随访期间，我们观察到双着丝粒产额在第25个月前下降了约7倍，此后几乎保持恒定。由于下降直到暴露后约第10个月才开始，因此在本研究中应谨慎考虑双着丝粒产额随时间呈指数下降的情况，尽管不能完全排除这种可能性。我们得出结论，在“生物剂量测定”中，暴露后应尽早采血。此外，对于局部身体高剂量照射后，考虑到采血延迟而计算淋巴细胞“半衰期”似乎并不确定。因此，在这种情况下，照射后1年或更长时间获得的剂量估计值应被视为最小值。
