新型利尿β受体阻滞剂盐酸替诺洛尔的分析概况
Analytical profile of the new diuretic beta-blocking agent tienoxolol hydrochloride.
作者信息
Guechot C, Bertrand A, Cramaille P, Teulon J M
机构信息
Analytical Development Department, Laboratoires UPSA, Rueil-Malmaison, France.
出版信息
Arzneimittelforschung. 1988 May;38(5):655-60.
PMID:2901263
Abstract
Physicochemical properties, i.e. elemental analysis, spectra (NMR, MS, IR, UV), solubilities, pKa, partition coefficient, melting point, HPLC, and data on purity and stability of ethyl 2-(3-[(1,1-dimethylethyl)amino]-2-hydroxy-propoxy)-5-[(2- thienylcarbonyl)amino]benzoate hydrochloride (tienoxolol), a new drug with antihypertensive properties are reported.
摘要
报道了具有抗高血压特性的新药2-(3-[(1,1-二甲基乙基)氨基]-2-羟基丙氧基)-5-[(2-噻吩基羰基)氨基]苯甲酸乙酯盐酸盐（替诺洛尔）的物理化学性质，即元素分析、光谱（核磁共振、质谱、红外、紫外）、溶解度、pKa、分配系数、熔点、高效液相色谱，以及纯度和稳定性数据。
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