Barad M, Jack T, Chadwick R, McGinnis W
Department of Human Genetics, Yale University, New Haven, Connecticut 06511.
EMBO J. 1988 Jul;7(7):2151-61. doi: 10.1002/j.1460-2075.1988.tb03054.x.
The homeobox gene family of Drosophila appears to control a variety of position-specific patterning decisions during embryonic and imaginal development. Most of these patterning decisions determine groups of cells on the anterior-posterior axis of the Drosophila germ band. We have isolated a novel homeobox gene from Drosophila, designated H2.0. H2.0 has the most diverged homeobox so far characterized in metazoa, and, in contrast to all previously isolated homeobox genes, H2.0 exhibits a tissue-specific pattern of expression. The cells that accumulate transcripts for this novel gene correspond to the visceral musculature and its anlagen.
果蝇的同源异型框基因家族似乎在胚胎发育和成虫发育过程中控制着各种位置特异性的模式形成决策。这些模式形成决策大多决定了果蝇胚带前后轴上的细胞群。我们从果蝇中分离出了一个新的同源异型框基因，命名为H2.0。H2.0具有迄今为止后生动物中特征最为不同的同源异型框，并且与所有先前分离出的同源异型框基因不同，H2.0表现出组织特异性的表达模式。积累这种新基因转录本的细胞对应于内脏肌肉组织及其原基。
