胰高血糖素在甲状腺功能减退、正常和亢进小型猪中的糖调节功能。

Glucoregulatory function of glucagon in hypo-, eu- and hyperthyroid miniature pigs.

作者信息

Müller M J, Mitchinson P E, Paschen U, Seitz H J

机构信息

Klinische Endokrinologie, Medizinische Hochschule Hannover, FRG.

出版信息

Diabetologia. 1988 Jun;31(6):368-74. doi: 10.1007/BF02341505.

DOI:10.1007/BF02341505

PMID:2901376

Abstract

The glucoregulatory function of glucagon was investigated in hypo-, eu- and hyperthyroid miniature pigs. Infusion glucagon, (3 ng x kg body weight-1.min-1) transiently increased blood glucose (p less than 0.01) and hepatic glucose production (p less than 0.01) in euthyroidism, but was without effect in hyperthyroidism. Infusing glucagon plus somatostatin (2 ng x kg body weight-1.min-1 and 0.2 microgram x kg body weight-1.min-1) transiently increased blood glucose (delta 3.0 to 4.3 mmol/l) and hepatic glucose production (delta 3.3 to 7.7 mumol x kg body weight-1.min-1) in all thyroid states, the effect was less pronounced in hyperthyroid pigs. By contrast, hypoglucagonaemia (74 to 107 pg/ml) at basal insulin (28 to 35 microU/ml) provoked hypoglycaemia (1.4 to 2.2 mmol/l) and a fall in glucose production (delta 4.7 to 8.3 mumol x kg body weight-1.min-1), which was independent of the thyroid state; the effect was most pronounced in hyperthyroidism (p less than 0.01). Hepatic glycogen content, arterial gluconeogenic precursor concentrations as well as the glycaemic response (delta 0.60 mmol/l) to alanine infusion (23 mumol x kg body weight-1.min-1) were all unaffected by hyperthyroidism. We conclude that moderate experimental hyperthyroidism reduces glucagon action due to reduced glycogen mobilisation. This may in part result from increased insulin sensitivity.

摘要

在甲状腺功能减退、正常和亢进的小型猪中研究了胰高血糖素的血糖调节功能。在甲状腺功能正常的情况下，输注胰高血糖素（3 ng·kg体重⁻¹·min⁻¹）可使血糖短暂升高（p<0.01），肝葡萄糖生成增加（p<0.01），但在甲状腺功能亢进时无此作用。输注胰高血糖素加生长抑素（2 ng·kg体重⁻¹·min⁻¹和0.2 μg·kg体重⁻¹·min⁻¹）在所有甲状腺状态下均可使血糖短暂升高（δ3.0至4.3 mmol/l），肝葡萄糖生成增加（δ3.3至7.7 μmol·kg体重⁻¹·min⁻¹），在甲状腺功能亢进的猪中作用较弱。相比之下，基础胰岛素水平（28至35 μU/ml）下的低胰高血糖素血症（74至107 pg/ml）会引发低血糖（1.4至2.2 mmol/l）和葡萄糖生成下降（δ4.7至8.3 μmol·kg体重⁻¹·min⁻¹），且与甲状腺状态无关；在甲状腺功能亢进时作用最为明显（p<0.01）。甲状腺功能亢进对肝糖原含量、动脉糖异生前体浓度以及对丙氨酸输注（23 μmol·kg体重⁻¹·min⁻¹）的血糖反应（δ0.60 mmol/l）均无影响。我们得出结论，中度实验性甲状腺功能亢进会因糖原动员减少而降低胰高血糖素的作用。这可能部分是由于胰岛素敏感性增加所致。