α1-抗胰蛋白酶同源序列正常等位基因片段的杂合性与定位
Heterozygosity and localisation of normal allelic fragments for an alpha 1-antitrypsin homologous sequence.
作者信息
Kalsheker N A, Watkins G L
机构信息
Department of Medical Biochemistry, University of Wales College of Medicine, Royal Infirmary, Cardiff, UK.
出版信息
Hum Genet. 1988 Sep;80(1):108-9. doi: 10.1007/BF00451471.
PMID:2901394
Abstract
Approximately 10 kb downstream of the alpha 1-antitrypsin (AAT) gene is a homologous sequence. Two polymorphisms detected with the restriction enzymes BglII and EcoRI have been reported previously. We describe two additional polymorphisms with the restriction endonucleases TaqI and HindIII and, for all four restriction enzymes, we have mapped the fragments corresponding to the normal alleles in a cosmid clone.
摘要
在α1-抗胰蛋白酶（AAT）基因下游约10 kb处有一个同源序列。先前已报道了用限制性内切酶BglII和EcoRI检测到的两种多态性。我们描述了用限制性内切酶TaqI和HindIII检测到的另外两种多态性，并且对于所有四种限制性内切酶，我们已在一个黏粒克隆中定位了与正常等位基因相对应的片段。
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