运动神经元病中的异生物质代谢

Xenobiotic metabolism in motor neuron disease.

作者信息

Steventon G, Williams A C, Waring R H, Pall H S, Adams D

机构信息

Department of Neurology, Queen Elizabeth Medical Centre.

出版信息

Lancet. 1988 Sep 17;2(8612):644-7. doi: 10.1016/s0140-6736(88)90467-9.

DOI:10.1016/s0140-6736(88)90467-9

PMID:2901517

Abstract

Debrisoquine, carbocysteine, and paracetamol were selected as safe drugs to investigate the ability of the liver's microsomal system to oxidise carbon, oxidise sulphur, and conjugate sulphate in patients with motor neuron disease (MND), other hospital patients, and healthy volunteers. Subjects with poor sulphur-oxidising and sulphur-conjugating activities were heavily over-represented in the MND group.

摘要

选用异喹胍、羧甲司坦和对乙酰氨基酚作为安全药物，以研究运动神经元病（MND）患者、其他住院患者及健康志愿者肝脏微粒体系统氧化碳、氧化硫和硫酸结合的能力。硫氧化和硫酸结合活性较差的受试者在MND组中所占比例过高。