Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China; Department of Laboratory Medicine, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China.
Department of Dermatology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China.
Cytokine. 2018 Apr;104:92-97. doi: 10.1016/j.cyto.2017.09.034. Epub 2017 Oct 7.
Interleukin (IL) 13 plays a critical role in inflammatory diseases, including systemic lupus erythematosus (SLE). This study aims to explore the potential association of IL-13 polymorphisms with the risk of SLE. We genotyped IL-13 rs20541, rs848 and rs1295686 using Snapshot SNP genotyping assays. Plasma IL-13 level was determined by enzyme-linked immunosorbent assay (ELISA). We found that rs20541 was associated with increased risk of SLE (CT vs. CC: adjusted OR=1.43, 95%CI, 1.04-1.99, P=.030; TT vs. CC: adjusted OR=1.73, 95%CI, 1.10-2.73, P=.018; CT/TT vs. CC: adjusted OR=1.50, 95%CI, 1.10-2.04, P=.010; T vs. C adjusted OR=1.34, 95%CI, 1.08-1.93, P=.031). CT and TT genotypes in rs20541 were associated with increased risk of renal disorder in SLE (CT vs. CC: adjusted OR=1.97, 95%CI, 1.18-3.28, P=.009; TT vs. CC: adjusted OR=2.42, 95%CI, 1.22-4.77, P=.011). Moreover, The concentration of IL-13 was significantly elevated in rs20541 CT/TT genotypes compared with CC genotype (P<.001). These results suggest that rs20541 CT/TT genotypes may be a risk factor for SLE, probably by increasing the level of IL-13.
白细胞介素 (IL) 13 在炎症性疾病中发挥着关键作用，包括系统性红斑狼疮 (SLE)。本研究旨在探讨 IL-13 多态性与 SLE 风险的潜在关联。我们使用 Snapshot SNP 基因分型检测方法对 IL-13 rs20541、rs848 和 rs1295686 进行基因分型。采用酶联免疫吸附试验 (ELISA) 测定血浆 IL-13 水平。我们发现 rs20541 与 SLE 风险增加相关 (CT 与 CC：调整后的 OR=1.43，95%CI，1.04-1.99，P=.030；TT 与 CC：调整后的 OR=1.73，95%CI，1.10-2.73，P=.018；CT/TT 与 CC：调整后的 OR=1.50，95%CI，1.10-2.04，P=.010；T 与 C 调整后的 OR=1.34，95%CI，1.08-1.93，P=.031)。rs20541 中的 CT 和 TT 基因型与 SLE 肾脏疾病风险增加相关 (CT 与 CC：调整后的 OR=1.97，95%CI，1.18-3.28，P=.009；TT 与 CC：调整后的 OR=2.42，95%CI，1.22-4.77，P=.011)。此外，与 CC 基因型相比，rs20541 CT/TT 基因型的 IL-13 浓度显著升高 (P<.001)。这些结果表明，rs20541 CT/TT 基因型可能是 SLE 的危险因素，可能通过增加 IL-13 的水平。
