碳硼烷连接的2'-脱氧尿苷5'-O-三磷酸作为用于聚合酶合成碳硼烷修饰DNA的构建模块。
Carborane-linked 2'-deoxyuridine 5'-O-triphosphate as building block for polymerase synthesis of carborane-modified DNA.
作者信息
Balintová Jana, Simonova Anna, Białek-Pietras Magdalena, Olejniczak Agnieszka, Lesnikowski Zbigniew J, Hocek Michal
机构信息
Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, CZ-16610 Prague 6, Czech Republic.
Institute of Medical Biology, Polish Academy of Sciences, Laboratory of Molecular Virology and Biological Chemistry, 106 Lodowa St., Lodz 93-232, Poland.
出版信息
Bioorg Med Chem Lett. 2017 Nov 1;27(21):4786-4788. doi: 10.1016/j.bmcl.2017.09.064. Epub 2017 Sep 30.
5-[(p-Carborane-2-yl)ethynyl]-2'-deoxyuridine 5'-O-triphosphate was synthesized and used as a good substrate in enzymatic construction of carborane-modified DNA or oligonucleotides containing up to 21 carborane moieties in primer extension reactions by DNA polymerases.
5-[(对-碳硼烷-2-基)乙炔基]-2'-脱氧尿苷5'-O-三磷酸被合成出来，并在DNA聚合酶进行的引物延伸反应中用作酶促构建含碳硼烷修饰的DNA或含有多达21个碳硼烷部分的寡核苷酸的良好底物。
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