Department of Neurophysiology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
Department of Neurophysiology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
Neurobiol Dis. 2018 Jan;109(Pt A):54-63. doi: 10.1016/j.nbd.2017.10.005. Epub 2017 Oct 7.
Lack of adequate sleep has become increasingly common in our 24/7 society. Unfortunately diminished sleep has significant health consequences including metabolic and cardiovascular disease and mental disorders including depression. The pathways by which reduced sleep adversely affects physiology and behavior are unknown. We found that 6h of sleep deprivation in adult male rats induces changes in neuronal activity in the lateral hypothalamus, the paraventricular nucleus, the arcuate nucleus and the mammillary bodies. Surprisingly, these alterations last for up to 48h. The data show that sleep loss has prolonged effects on the activity of multiple hypothalamic areas. Our data indicate also that measuring electroencephalographic slow wave activity underestimates the amount of time that the hypothalamus requires to recover from episodes of sleep deprivation. We propose that these hypothalamic changes underlie the well-established relationship between sleep loss and several diseases such as metabolic disorders, stress and depression and that sufficient sleep is vital for autonomic functions controlled by the hypothalamus.
在我们的 24/7 社会中，睡眠不足变得越来越普遍。不幸的是，睡眠不足会对健康产生重大影响，包括代谢和心血管疾病以及精神障碍，如抑郁症。睡眠减少对生理和行为产生不利影响的途径尚不清楚。我们发现，成年雄性大鼠 6 小时的睡眠剥夺会导致外侧下丘脑、室旁核、弓状核和乳头体的神经元活动发生变化。令人惊讶的是，这些改变可持续长达 48 小时。数据表明，睡眠不足对多个下丘脑区域的活动有持久的影响。我们的数据还表明，测量脑电图慢波活动低估了下丘脑从睡眠剥夺发作中恢复所需的时间。我们提出，这些下丘脑变化是睡眠不足与代谢紊乱、压力和抑郁等多种疾病之间已确立关系的基础，而充足的睡眠对下丘脑控制的自主功能至关重要。
