Chen Pinqiu, Ban Weikang, Wang Wenyan, You Yuyang, Yang Zhihong
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, School of Pharmacy, Yantai University, Yantai 264005, China.
Clocks Sleep. 2023 May 15;5(2):276-294. doi: 10.3390/clockssleep5020022.
In this narrative review article, we discuss the role of sleep deprivation (SD) in memory processing in rodent models. Numerous studies have examined the effects of SD on memory, with the majority showing that sleep disorders negatively affect memory. Currently, a consensus has not been established on which damage mechanism is the most appropriate. This critical issue in the neuroscience of sleep remains largely unknown. This review article aims to elucidate the mechanisms that underlie the damaging effects of SD on memory. It also proposes a scientific solution that might explain some findings. We have chosen to summarize literature that is both representative and comprehensive, as well as innovative in its approach. We examined the effects of SD on memory, including synaptic plasticity, neuritis, oxidative stress, and neurotransmitters. Results provide valuable insights into the mechanisms by which SD impairs memory function.
在这篇叙述性综述文章中，我们讨论了睡眠剥夺（SD）在啮齿动物模型记忆处理中的作用。众多研究已经考察了睡眠剥夺对记忆的影响，大多数研究表明睡眠障碍会对记忆产生负面影响。目前，对于哪种损伤机制最为合适尚未达成共识。睡眠神经科学中的这个关键问题在很大程度上仍然未知。这篇综述文章旨在阐明睡眠剥夺对记忆产生损害作用的潜在机制。它还提出了一个可能解释某些研究结果的科学解决方案。我们选择总结具有代表性、全面性且方法创新的文献。我们考察了睡眠剥夺对记忆的影响，包括突触可塑性、神经炎、氧化应激和神经递质。研究结果为睡眠剥夺损害记忆功能的机制提供了有价值的见解。
