石楠藤内生真菌 Phyllosticta sp. 中多生源衍生的倍半萜类化合物 Phyllomeroterpenoids A-C 及其抗微生物活性。
Phyllomeroterpenoids A-C, Multi-biosynthetic Pathway Derived Meroterpenoids from the TCM Endophytic Fungus Phyllosticta sp. and their Antimicrobial Activities.
机构信息
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, People's Republic of China.
Clinical Experimental Center, First Affiliated Hospital of Jinan University, Guangzhou, 510632, People's Republic of China.
出版信息
Sci Rep. 2017 Oct 10;7(1):12925. doi: 10.1038/s41598-017-13407-y.
Phyllomeroterpenoids A-C (1-3), multi-biosynthetic pathway derived meroterpenoids from amino acid/pentose phosphate/terpenoid pathways, were isolated from the TCM endophytic fungus Phyllosticta sp. J13-2-12Y, together with six biosynthetically related compounds (4-9). All structures were determined by extensive spectroscopic analysis, chemical derivatization, and ECD experiments. A plausible biosynthetic pathway of 1-3 was proposed. In addition, the antimicrobial activities of all isolated compounds were evaluated against Staphylococcus aureus 209P (bacterium) and Candida albicans FIM709 (fungus).
菲螺萜烯类化合物 A-C（1-3）是从中药内生真菌 Phyllosticta sp. J13-2-12Y 中分离得到的多生物合成途径的氨基酸/戊糖磷酸/萜烯途径衍生的倍半萜类化合物，此外还分离得到了六个生物合成相关的化合物（4-9）。所有结构均通过广泛的光谱分析、化学衍生化和 ECD 实验确定。提出了 1-3 的可能生物合成途径。此外，还评估了所有分离得到的化合物对金黄色葡萄球菌 209P（细菌）和白色念珠菌 FIM709（真菌）的抗菌活性。
Zotero 插件