Engwerda Anthonius H J, van Schayik Pim, Jagtenberg Henjo, Meekes Hugo, Rutjes Floris P J T, Vlieg Elias
Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Cryst Growth Des. 2017 Oct 4;17(10):5583-5585. doi: 10.1021/acs.cgd.7b01180. Epub 2017 Sep 13.
The scope of Viedma ripening and temperature cycling with respect to chiral molecules has remained mostly limited to molecules with a single stereogenic center, while racemization proceeds through inversion at that particular stereocenter. In this article we demonstrate for the first time that atropisomers, chiral rotamers that possess an axis of chirality, can be successfully deracemized in the solid phase by either applying temperature cycling or Viedma ripening.
关于手性分子的维德马熟化和温度循环的范围大多仍局限于具有单个手性中心的分子，而外消旋化是通过该特定手性中心的构型翻转进行的。在本文中，我们首次证明，通过温度循环或维德马熟化，具有手性轴的阻转异构体（手性旋转异构体）能够在固相中成功地实现去消旋化。
