Takada M, Li Z K, Hattori T
Department of Anatomy, University of Toronto, Ont., Canada.
Brain Res. 1988 Aug 2;457(1):165-8. doi: 10.1016/0006-8993(88)90070-4.
After injecting a fluorescent tracer (Fluoro-gold) into the rat superior colliculus, retrogradely labeled neurons in the rostral, ventrolateral portions of the substantia nigra pars reticulata were also immunohistochemically labeled with tyrosine hydroxylase antisera. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) pretreatment of the medial forebrain bundle resulted in the disappearance of the nigral neurons double-labeled with the two markers. The existence of a dopaminergic nigrotectal projection susceptible to MPTP might provide a morphological substrate for abnormal saccadic eye movements in parkinsonism.
